Tortoise shell cats

That is not really how it works Dave. The genes are at different loci in the genome. The orange and black are different versions of the same gene, and the white is the result of a gene at a different place on the genome. I think the white spotting is recessive so if you crossed a calico and white female with an orange and white male all offspring would have white spotting. Half of the males would be black and white with half being orange and white. Half of the females would be orange and white and half would be calico and white. A black and white male in this cross would result in half of the females being black and white instead of orange and white.

The white spotting gene is not a pigment gene, but rather a gene that influences the distribution of pigment producing cells. Where the pigment producing cells, called melanocytes, end up in the skin is where you see colored fur (either black or orange). Where no melanocytes end up there is no pigment production and the result is white fur. The normal gene allows melanocytes to cover the whole body. The mutant version results in patchy distribution of melanocytes.

John

Maybe not fur color, but I’m sure there’s some sort of genetic predisposition. My cat, Beru, is part Siamese. Siamese cats tend to be very territorial, and get jealous very easily. Beru hates everyone but me. If someone comes over to my apartment, Beru will hiss, growl, and run off. A few minutes later, she’ll reappear, but sit just inside the doorway and glare at the other person.

My grandmother has a full-blooded Siamese named Mozart, and was the exact same way. Anyone except her who tried to pet him was subect to severe bites and scratches. Not as a warning: Mozart was going all like like he wanted to kill your hand.

My boyfriend has a Siamese (she’s very close to full-blooded), and she’s very friendly, cuddly, and nice (although very vocal). She craves attention from anyone in the apartment, including the other (tortie) cat (Not my tortie… this one’s very affectionate, easygoing, and nice). I don’t know. I guess there’s not that much genetic accounting for cat temperament, unless the cat is closer to full-bred, perhaps. My cat’s very much a mutt of the cat world.

My boyfriend has a Siamese (she’s very close to full-blooded), and she’s very friendly, cuddly, and nice (although very vocal). She craves attention from anyone in the apartment, including the other (tortie) cat (Not my tortie… this one’s very affectionate, easygoing, and nice). I don’t know. I guess there’s not that much genetic accounting for cat temperament, unless the cat is closer to full-bred, perhaps. My cat’s very much a mutt of the cat world.

don willard, ‘brown’ is a generic term for any cat whose coloration is based on the eumelanin pigment. ‘Black’ is not a separate color - it is the result of a LOT of eumelanin pigment deposited in the hair, giving it a ‘black’ appearance. Another gene, the agouti gene, determines whether or not a cat will have a visible pattern or appear solid colored; it’s counterpart on the chromosome alignment is the recessive non-agouti.

A ‘black’ cat is a brown tabby that is homozygous for non-agouti - instead of having pigment deposited in the hair in such a way that a pattern is visible, the pigment is evenly deposited at the same intensity all over the body, hence a solid-colored cat. (BTW, the agouti gene only affects eumelanin pigment - all orange cats have a visible pattern, no matter what their agouti/non-agouti status. While an orange cat may be genetically non-agouti, or solid, it will always have a visible pattern of some kind.)

So Blackie-next-door is still a ‘brown’ cat, but he is a non-agouti (solid) so has such heavy pigmentation that he appears black. FWIW, ‘brown’ includes: black, blue, chocolate, cinnamon, lilac, and fawn, and may include silver, which can act on either eumelanin or phaeomelanin.

I don’t know a thing about dog genetics, but this isn’t true in cats. It is just very common because, in cats, the gene that causes such white markings is dominant.

It means he LIKES you - a LOT. I see that several people have mentioned temperament/personality, so I’ll take a stab at addressing that here. There is still a lot of argument over this, but feline temperament seems to be a combination of inheritance and early socialization. I work with a couple of breeds that have VERY recent wild ancestors, and temperament is a big issue. Part of it is certainly inherited - a kitten that inherits the temperament of its wild ancestor will NEVER be a friendly, loving pet no matter how well socialized it has been. You may be able to handle it, but you will never be friends.

A kitten that inherits a domestic-type temperament still requires human socialization. Although they take some cues from their dam, even kittens from a wild mother will be friendly if they have a propensity for it AND are handled properly when young (primarily between 3 and 8 weeks of age). Some kittens hardly need any encouragement to regard humans as friends, while others need daily gentle handling to develop their trust. Some will bond well with a single person and regard everyone else with distrust, while others seem to think that every human is their surrogate mom.

A cat’s ability or desire to interact with humans seems to be based on an inherited tendency to prolonged kittenhood. Purring and kneading are behaviors associated with nursing; drooling seems to be an extreme exhibition of this ‘happy’ behavior. I once had a drooler who, unfortunately, also became so excited that she farted during heavy petting sessions. :rolleyes: My guess is that her emotions were so intense that they not only stimulated salivation, they also activated her digestive system! She was a bottle-raised orphan, BTW, which may have accounted for her extreme behavior.

k2dave, it is not NEARLY that simple. The gene that governs the production of ‘brown’ (eumelanin) pigment is present in ALL cats. The Orange gene is located on an entirely separate chromosome; when present, it interferes with the production of eumelanin, converting it to phaeomelanin (orange) instead. White-spotting is governed by still another gene, and operates independently of either the ‘B’ gene or the ‘O’ gene.

So, leaving the white spotting out of it, you are forgetting that all matings do not involve brown/orange combinations. Mating brown to brown produces only brown offspring; mating orange to orange produces only orange offspring; mating brown to orange produces tortoiseshell females and either brown or orange males, depending on which parent is which color.

In matings that involve combinations of brown and orange (including tortoiseshells), the number of orange males is statistically higher because only one combination - orange male to tortie female - can produce orange females. However, all orange cats are not produced by combination matings. So this is not true for the entire cat population, only those matings that involve brown/orange combinations. Orange to orange matings will produce, on average, equal numbers of orange females and orange males.

Thing 1, very, very good! The only quibble is that the white-spotting gene appears to be a dominant with incomplete penetrance, rather than a recessive. It also appears to be cumulative - breeding two cats with white markings usually results in offspring with larger amounts of white than the parents. There are three ways that white cats can be created:

Dominant white, which is a gene that inhibits melanocyte production very early in embryonic development and results in a solid white cat, often with blue or odd eyes, and sometimes suffering from deafness.

White-spotting factor, apparently a dominant gene with incomplete penetrance. It inhibits melanocyte production in discrete areas instead of affecting the entire cat as a whole. Since it appears to have a cumulative effect, repeated breedings of cats with more and more white can eventually result in a solid white cat, although this is rare.

The albino series, which inhibits pigment production through temperature sensitivity - warm temperatures inhibit pigment production. This series produces the pointed cats, like the Siamese. This gene (the full-color gene) has 4 known mutations that cause varying degrees of heat-sensitivity in the pigment: sepia (the Burmese breed is based on this mutation), pointed (the Siamese breed is based on this mutation), blue-eyed albino (rare), and pink-eyed albino (extremely rare). Sepia and pointed are co-dominant - a cat with one sepia and one pointed gene will exhibit markings between the two extremes, and is called a mink (the Tonkinese breed is based on the mink combination).

TMI, I’m sure - but I don’t get an excuse to rattle on about this stuff very often!

Yeah, I was not sure if it was dominant or recessive. I know many coat color mutations are recessive and it made the genetics easier. Do you know the genes that these mutations represent? Dominant white sounds similar to mutations in the Kit gene. Perhaps white spotting factor is a mutation in the endothelin recepor? I also find it interesting that melanocytes can affect hearing. Apparently melanocytes do something besides produce pigment that is required by the inner ear.
John

After reading the above posts I now know that I have a Calico cat and not a true Tortie. She has random patches of black and orange(we call it ginger in the UK) over the upper part of her body. Her chest and tummy is white , as is most of here face and part of her neck. When her side was shaved for spaying I noticed that her skin was also a patchwork of pink and black. The pink skin produced orange fur and the black skin black fur. Another strange thing :- both her front paws have a random mixture of black and pink pads,is this usual?. One last thing I thought a female cat was called a “Queen” and not a “Dam”

coosa, I find this all incredibly fascinating, cat genetics. I wonder if you could perhaps recommend two or three good books on the subject? Robinson’s Genetics for Cat Breeders and Veterinarians isn’t in the library.

I’m always on the lookout for books about cats with more words than pictures.

-fh

So, coosa (my word what expertise you have!), what’s the scoop on “one-person-ness”? The Siamese I grew up with was like Superdude’s, totally devoted to one person (for the first 8 years or so, my mom) while at best tolerating everyone else. The most difficult thing for her was when my mother died, quite unexpectedly and away from home. The cat went through weeks of disorientation before she settled down with my father, but then became as one with him as she’d been with Mom.

Sorry it’s taken me so long to answer - I seem to have come down with the flu and have been clinging to my bed for a couple of days. But, hey, I’m a Doper, so I’ve crawled from my death-bed to further the fight against ignorance! :wink:

Okay, John, I’ve had to look some stuff up in order to try to give you some good answers. I’d like to mention that feline genetics is in its infancy - until recently there has not been a lot of motivation to fund extensive research in this area. A lot of what we know about color genetics and such has been derived from test breedings by various scientific professionals who also happen to be interested in breeding cats.

Hmm, I keep trying to post some links and every time I do it screws up the post. I’m going to try to post the links in a following post and see what happens.

Briefly, a portion of the ear called the stria vascularis contains melanocytes whose function are unknown but are apparently essential. The genes that cause white coat coloring in some cats and dogs do so by interfering in various degrees with melanocyte production during early embryo formation. If melanocytes do not migrate to this portion of the inner ear during embryonic formation, the inner ear will begin to degenerate shortly after birth, usually resulting in complete deafness within a few weeks. This is the type of deafness commonly seen in Dalmation dogs.

In cats, the genes known to create white coat hair in this manner are ‘dominant white’(W) and ‘white spotting’(S). ‘W’ results in a completely white cat, while ‘S’ normally allows varying degrees of pigmentation. Deafness in ‘S’ cats is pretty rare, as one of the last areas to lose pigmentation is the top of the head. Deafness occurs most often in ‘W’ cats with blue eyes (BEWs - blue-eyed whites) because the blue irises are due to lack of pigmentation, and if pigment cells failed to migrate to the eyes, they are more likely to have failed to reach the ears, also. However, ‘W’ cats with normal-colored eyes can also be deaf, and ‘odd-eyed’ cats - those with one blue eye and one normal colored eye - may be deaf only in one ear, on the same side as the blue eye.

This has been compared to Waardenburg’s Syndrome in humans, but as far as I know no connection has yet been established. The similarities ARE eerie, though.

Anyway, it’s not that the melanocytes do anything besides produce pigment needed for the inner ear - the problem is that without those melanocytes, the inner ear will degenerate and cease functioning!

And I can’t answer you question about which genes are responsible, because as far as I can tell no one knows yet! I’ll have to do some research at PubMed and such to see if anything has recently been published - I think we can expect to see some major advancements in knowledge about feline genetics very soon, partly because of the on-going Feline Genome Project, and partly because researchers are discovering that feline and human genetics are very, very similar. Domestic cats are already very popular research subjects because of certain similarities to humans - the brain structure is very close, for example. And certain feline abnormalities - such as the deafness discussed here and the dwarfism seen in Munchkin cats - may be very helpful in learning more about similar or identical human conditions.

David Cronan, pigmented skin under the hair is common - whether it is there or not may depend on underlying modifier genes. But two-toned pawpads are common on cats with any white markings, because the pawpads are pigmented. In this case it is just an extension of the pigmentation visible in the hair - if the pawpads had hair, the black ones would have black hair and the pink ones would have either orange or white hair. Another little goody I’ll stick in here - pawpad and nose leather color are important characteristics cat breeders use to determine the true genotype of their cats.

And you’re correct, a female cat is called a ‘queen’. ‘Dam’ simply means that you are referring to the female parent of pretty much any animal, just as ‘sire’ means you are referring to the male parent. As far as I know, this is universally used across all species when discussing parentage. It’s just the accepted way of saying ‘mother’.

hazel-rah, as far as good books on cat genetics, Robinson’s is ‘the Bible’. I’m not suprised that your library doesn’t have it, though, because it’s not something a lot of people are interested in. The latest edition only came out in 1999 so there aren’t going to be a lot of used ones available, but you might check on e-Bay and/or have Amazon or someone put you on a waiting list for a used one. New ones cost $65.00! Gloria Stephens has a new book out called Legacy of the Cat, Volume II (I think - anyway, there are two editions, one brand new). It’s more of a coffee-table type book with lots of pics by a world famous Japanese cat photographer, but also has a lot of good genetic info. Another good book is Feline Husbandry: Diseases and Management in the Multiple-Cat Environment by Dr. Niels C. Pedersen, one of the foremost feline researchers in the world. That’s another pricey book! It is supposed to be out of print, but you can get one at http://www.revivalanimal.com Oh, and you might really like a book called The Domestic Cat: The biology of its behavior, edited by Dennis C. Turner & Patrick Bateson. I found my copy at Amazon - I can’t remember the price, but seems like it was about $20.00. I have to order a new copy, as my cats got hold of mine and ‘behaved’ all over it. But it is absolutely fascinating!

You might see if your library can ‘borrow’ books from other libraries. Or see if you can buy the book, then donate it to the library and deduct it from your taxes!

OxyMoron, I can’t give you a definitive, by-the-book answer, just the conclusions I’ve reached from years of working with, and associating with other breeders of, the wild-hybrid breeds. Many cat fanciers will disagree and claim that everything is due to early socialization, but working with cats that are not purely domestic provides a unique viewpoint.

Bear in mind that domestic cats have not been bred selectively for thousands of years, as have dogs. Cats seem to have become domesticated accidentally by hanging around human habitations once we started storing food that attracted rodents. Organized cat breeding - the ‘cat fancy’ - didn’t really start until about 100 years ago, and focused mainly on preserving different body types, hair lengths, and colors.

Domestic cats have not been selectively bred for temperament (until recently), although the ability to tolerant other members of their species and others (like humans) created a sort of natural selection process. Degrees of ‘socialibility’ vary a great deal from individual to individual. ‘One-person’ cats are, in my opinion, cats that have inherited a temperament very close to that of their wild ancestors, who are more solitary by nature. It is difficult for these cats to be comfortable in ‘crowds’ - they are able to form a close relationship with one person, but their ‘hard-wiring’ makes it difficult or impossible for them to do more than grudgingly tolerate any additional people or animals.

This can be exacerbated by the conditions in which they are reared and live most of their lives. If they are taken from their mother at a very young age (many people think 6 weeks is appropriate - it’s NOT) and from that time forward live with only one or two people without much outside contact (and most of that comprising trips to the vet, not usually a happy experience) they do not develop any social skills, nor any tolerance for strangers. A cat that was raised in this manner but inherited a ‘domestic’ personality may adjust and even thrive in a new situation, while one with the original ‘wild-type’ personality may not. I’ve heard of cats that actually ‘pined away’ after their owner died because they could not make the adjustment.

And if you’re all really nice to me, I’ll tell you why Siamese (and all other blue-eyed pointed cats) are different from other cats! :smiley: But me and my buddy the flu need to take a break and be miserable together for a little while.

Okay, I don’t know why this won’t work as hyperlinks - I don’t know if it is the board or my computer that is screwing up.

Deafness in Dogs and Cats
http://www.lsu.edu/deafness/intro.htm

The Pigment Parade
http://home.earthlink.net/~featherland/off/white.html

Thank you so much for the recommendations! Amazon lists the Pedersen book on 2-3 day availability for $49, and the other two are around $15 each.

I’ve been looking to go a bit deeper into the cat literature, but I didn’t know where to go. My favorite so far is “The Cat’s Mind” by Bruce Fogle or “Cats are Not Peas: A Calico History of Genetics” by Laura Gould. If you’ve read either of them I’d love to know what you thought of them… the latter is a nice introduction to genetics and has one of my favorite book titles ever.

And get well soon!

-fh