The Simpsons - had 8 great seasons, and then Matt Groening left to work on Futurama and the show tanked, and never recovered. I actually stuck with it until season 12, when I finally decided enough is enough. I occasionally check in on it, and no, it hasn’t recovered yet.
Heroes - stayed with it until halfway through the third season. I gave it more of a chance than most people (although I was so tempted to quit when they kept having that stupid crying central-American woman), but it just got more and more boring to watch.
House MD - I stopped watching once I realized that every episode was exactly the same
Original Law & Order - I watched this show for years, but once Jack became the new head lawyer and Brenda’s brother and Antwon became the new cops, it became dull very fast. I still watch SVU, but it’s mostly for hot-female-lawyer-love.
Grey’s Anatomy - yeah, I actually watched a season of it. I never liked it, but EVERY SINGLE WOMAN I KNEW was watching the show, so I tried to keep up with them for a while.
Criminal Minds - stopped watching when Gideon left. Fat Tony as a criminal profiler just didn’t work for me. I’m still being compared to Dr Reid on a regular basis.
CSI - I stopped watching when it stopped being about real science (which was right around when the show became #1 somehow)
Lost - I actually gave up on after that 7 episode mini-season where absolutely NOTHING happened. I finally came back after I kept hearing that the show finally got its shit back together, but as a policy I only watch a season at a time, so I haven’t seen any of the current season yet.
Amazing Race - used to be one of my favorite shows. But when they stopped having the teams solve puzzles and were just told where to go next, and when they started rigging it where no matter what, EVERYONE would be stuck at the airport in the end, it lost any remaining appeal.
The Apprentice - once the show became an hour long commercial of the week, I was done.
Family Guy - I still check in on this one now and then, but it was never the same after cancellation. Whatever happened to Stewie being a world-conquering villain?
SNL - I come and go with this show a lot. After Tina left the show, and it became the Amy & Kristen show (two actresses who are ALMOST, ALMOST as annoying as Molly Shannon) I was mostly gone. But goddamn, Tina dragged me back last night. Can’t she just host every week?
Prison Break - this excellent show only had 2 seasons, and everything got wrapped up perfectly. As far as I’m concerned, the last 5 minutes of the season finale, and any additional seasons or movies NEVER HAPPENED.
24 - after that horrific 6th season, where all they did was recycle themes from seasons 1-5, I was sick of it. The year long hiatus didn’t help either.
I’ve been rewatching Malcolm in the Middle over the last couple of days and now I remember why I stopped watching it - after having 4 HILARIOUS AND CLASSIC seasons, Malcolm becomes a bigger dick than Reese and only acts smart when it’s convenient to the plot. Plus, the baby shark jump.