Not exactly huge names that everyone would recognize, but maybe indy fans like lissener might:
Marianna Palka wrote, directed and starred in the compelling indy flick Good Dick, but appears to have nothing else on the horizon. That movie’s biggest WTF moment had to be a surprising cameo by a big starlet and her husband as a couple renting a movie from the video store where a main character works.
The stunningly beautiful Rebecca Mozo really only ever appeared in the campy-fun indy flick Zerophilia. She looks like a cross between Winona Ryder and Keira Knightley, so naturally the first time I saw her on screen I figured she was destined to be a star. Yet her imdb page has been basically empty for years. I see she finally has another movie in the works, but don’t recognize anyone on the cast.
EDIT: Heh, I was going to say Nikki Reed peaked at the age of 14 when she wrote and starred in the fantastic Thirteen, but I see on her imdb page that she’s in the Twighlight movies so I guess she doesn’t count.