Ulysses (Lonesome Road add-on for Fallout: New Vegas)
Velvet Velour (Vampire: The Masquerade - Bloodlines) - known as “V.V.” to her close friends.
George Washington, leader of the American faction in the Civilization series
Xion. (Kingdom hearts)
Yoshi, from many Super Mario games
Zemus/Zeromus, the Big Bad from Final Fantasy IV.
Astaroth, one of my favorite fighters from the Soul Calibur series.
Bartz Klauser (or Butz, or Batz) - protagonist of Final Fantasy V.