Hm. How 'bout this example:
Finding a sweater at the thrift shop – brand new and lovingly knitted or crocheted by hand – clearly as a gift, but obviously never worn (like some well-intentioned granny knit a hideously out-of-style sweater).
Another one that gets me with pangs of saddness is if I find a really great book in a used bookstore – one in mint condition that has clearly never been opened and read – and the inside front cover has a deep, meaningful and heartfelt inscription. (Especially if the inscription is dated quasi-recently showing that the book was discarded quickly.)