Well, facing specifically the US I’d go with our current political deadlock and the lack of bi-partisan compromise and the national debt which is at staggering levels and is already causing major issues that will only get worse as it continues to rise.
Globally, I’d say global warming is certainly one of the big ones. The rest of those I don’t think are as bad as our political deadlock and increase in partisanship and our debt issues. I was going to say Trump is one of the ‘REAL’ problems we are facing, but he’s more a symptom of the first one (i.e. deadlock and partisanship) and certainly is doing is part to exacerbate the second.