What is your acceptable failure rate for a vaccine?

[sweat209]

Yea WE EVEN got Hepatitis, Herpes,HPV and Chlamydia vaccine but no HIV vaccine.

[Voyager]

@sweat209

It is funny how there is flu vaccine every year :D:D some times many flu vaccines every year but no HIV vaccine.

We even got Ebola vaccine in not even year time. The same with swine flu vaccine in very little time.

Yet 30+ years still no HIV vaccine.

It is not funny at all if you understood how vaccines work. There is a wide variety of vaccination mechanisms. There are a wide variety of ways in which diseases work.
Do you think that Big Pharma would pass up the massive profits that could be had from coming up with an HIV vaccine?

[Chihuahua]

I prefer to let trained scientists make decisions like these. Pass.

[Chronos]

What we learn from that is that HIV is a really tough virus to develop a vaccine for. It’s not like every vaccine is equally easy to develop. For that matter, we also still don’t have a vaccine for rhinovirus, and nobody ever assumes a political motive for that.

Back to the OP, I agree with others that we need to know a mode of transmission and a quantification of “sweeping the world” in order to make a decision, here. And if the vaccine can only be given to children, in the worst cases it’s not going to accomplish anything even with a 100% success rate: If all of the adults catch the disease from each other and die off, then all of the children will, too, very soon.

[sweat209]

@Voyager

It is not funny at all if you understood how vaccines work. There is a wide variety of vaccination mechanisms. There are a wide variety of ways in which diseases work.
Do you think that Big Pharma would pass up the massive profits that could be had from coming up with an HIV vaccine?

It is not different as there are many strains of flu. You can come up with flu vaccines that will help you this year that will not help you next you to they bring out other flu vaccines for next year.

There are many HIV strains just like there are many flu strains. So you need new HIV vaccine every year.

The Ebola vaccine and swine flu vaccine they did it in year.

[Jackmannii]

@sweat209

Yea WE EVEN got Hepatitis, Herpes,HPV and Chlamydia vaccine but no HIV vaccine.

There are no herpes or chlamydia vaccines yet in clinical use.

[naita]

@sweat209

It is not different as there are many strains of flu. You can come up with flu vaccines that will help you this year that will not help you next you to they bring out other flu vaccines for next year.

There are many HIV strains just like there are many flu strains. So you need new HIV vaccine every year.

HIV strains are not “just like” flu strains and there’s no reason for anyone to accept your conjecture that new HIV-vaccines would be required every year.

Furthermore there is some protection from even the wrong flu vaccine, as flu strains all share similarities.

Please offer some cites for at least your underlying concepts, but preferably also for your conclusions.

[sweat209]

@naita

HIV strains are not “just like” flu strains and there’s no reason for anyone to accept your conjecture that new HIV-vaccines would be required every year.

Furthermore there is some protection from even the wrong flu vaccine, as flu strains all share similarities.

Please offer some cites for at least your underlying concepts, but preferably also for your conclusions.

What do you mean by HIV strains are not like flu strains?

And flu strain is similar to other flu strain?

Are you saying flu strains don’t change much? A flu strain from 1980 to flu strain today is not that different?

Are you saying there may be hundreds of flu strains but they are not that different? But HIV strain of 2002 vs 2004 is very different?

[naita]

@sweat209

What do you mean by HIV strains are not like flu strains?

And flu strain is similar to other flu strain?

Are you saying flu strains don’t change much? A flu strain from 1980 to flu strain today is not that different?

Are you saying there may be hundreds of flu strains but they are not that different? But HIV strain of 2002 vs 2004 is very different?

You’re the one drawing conclusions counter to basic medical science, you get the honor of describing how your analysis is better than all of the world’s researchers in vaccines, influenza and HIV.

[sweat209]

@naita

You’re the one drawing conclusions counter to basic medical science, you get the honor of describing how your analysis is better than all of the world’s researchers in vaccines, influenza and HIV.

Answer the question because I DON’T understand what you are trying to say.

I forgot my crystal ball at home so I don’t know what you are trying to say about HIV strains vs flu strains?

[naita]

@sweat209

Answer the question because I DON’T understand what you are trying to say.

I forgot my crystal ball at home so I don’t know what you are trying to say about HIV strains vs flu strains?

I consider this discussion a derail of the thread, so I won’t contribute further to it. I only contributed to it in the first place because your post was so spectacularly wrong.

[sweat209]

@naita

I consider this discussion a derail of the thread, so I won’t contribute further to it. I only contributed to it in the first place because your post was so spectacularly wrong.

If it more completed then fine say so. Keep in mind not everyone at straightdope as degree in Virology here.

If it is more completed than strains than say so than spend next 4 to 6 replies posting sarcastic replies.

[naita]

@sweat209

If it more completed then fine say so. Keep in mind not everyone at straightdope as degree in Virology here.

If it is more completed than strains than say so than spend next 4 to 6 replies posting sarcastic replies.

This one is my fourth reply to you in this thread. Just sayin’.

[dracoi]

@sweat209

If it more completed then fine say so. Keep in mind not everyone at straightdope as degree in Virology here.

If it is more completed than strains than say so than spend next 4 to 6 replies posting sarcastic replies.

First hit on Google says:

in November 2005, pioneering HIV scientist Robert Gallo summarised the barriers to developing a vaccine and made recommendations as to future directions for research.5

He said HIV vaccine development was difficult because of the following factors:

An HIV vaccine cannot consist of attenuated, actively replicating (live) HIV, due to possible reactivation.
Killed whole virus (like the polio vaccine) might also be dangerous because one could not be sure one has killed all viral particles. A killed whole virus vaccine had also worked poorly in animal studies.
There were successful vaccines that use subunits of viruses such as individual proteins: an example was the hepatitis B vaccine. However medical science was less experienced with them.
There is no truly useful small animal model for studying HIV infectionand vaccines had to be developed in monkeys using SIV or the artificial monkey/human virus SHIV in monkeys, which did not have exactly the same immune effects as HIV.
We do not know with certainty which immune response will provide protection; this is a major problem. Pre-efficacy studies of vaccines in monkeys and humans used correlates of immunogenicity such as CD8 cell response, but we do not know whether this immune response is in fact a correlate of efficacy.
We have never before attempted to develop a vaccine against a retrovirus like HIV. Retroviruses, by integrating their genome into ours, are able to hide completely from immune surveillance within quiescent lymphocytes. This means that any vaccine has a small window of opportunity in which to prevent infection and would have to be extremely effective, repelling all attempts by HIV to attach to and infect host cells.
HIV produces viral proteins such as tat and vif that actively interfere with what would otherwise be a potent anti-HIV response in both infected and uninfected cells.
CD8 cellular vaccines do not block infection because they act at too late a stage, so, if they worked, would do so by reducing the viral load in chronic infection. They would not necessarily reduce the peak level of viraemia in the early burst of viral reproduction and might not control infections transmitted by people in acute infection.
HIV is capable of developing immunity to the CD8 cellular response.