In no particular order…
4 moves.
4 jobs.
2 children.
1 marriage.
1 divorce.
Quit smoking.
Moved away from my hometown.
Lost weight.
Joined a political party.
Learned to drive.
I joined in 2005.
The biggest change in my life in the past ten years has been my conversion from conservative Republican to bleeding-heart liberal Democrat. The factors that influenced that change are interesting to me in retrospect. The presidency of GWB drove me away from my previous position. My Christian faith, and particularly a prison ministry I got involved in, drew me toward a much more charitable view of people. And things I read here, or things I was led to read by comments and links on here, helped me to build an intellectual framework around what my heart was telling me.
As for milestones or events:
I got my BS in 2007 at the age of 53.
All five kids got married and so far have blessed us with five grandchildren with two more on the way.
Moved out of California (miss it every day)
Retired (happy about this every day)
Moved from California to Pittsburgh.
Had one kid, will be having another in July.
Socks.
Changed jobs.
Kids grew up.
Same house. Same wife, although she got her M.Div. and is now a pastor.
Leet the Wonder Dog[sup]TM[/sup] arrived in 2010, so I am now walking three miles a day (and getting up every morning at 5:58am, no matter what.)
Became a great-uncle five times (one more pending, I found out last night).
Spent a fair amount of time on the Dope, some of it wasted.
Regards,
Shodan
I got fatter.
Joined in 2001
Finished college
Ran away to grad school
Got engaged
Mother died
Engagement broke up
Ran away to the other side of the state
Finished grad school
Dated a lousy guy who sent my life down the chutes
17-year-old cat died
Kicked lousy guy to the curb
Working on getting life back together
Dad had a leg amputated
Changed religions
Wow, pretty much 1/3 of my life has happened since I joined here.
Joined June 2012.
Only major event since then is happening tomorrow…
Nephew with hypoplastic left heart syndrome will be born. Norwood procedure tomorrow or within the next week.
Left private practice, went into public practice, aka prison (where I still am). Kids grew up, left home, got married. Discovered the wife and I really like this empty nester stuff. Nice to know the reasons we wanted to be together originally (back in 1973) still apply.
Joined in May of 2000
Family
Got married 5 months after joining
Adopted a newborn son in 2010
Another son born the old-fashioned way in 2012
Career
Since joining I have been a:
Building Maintenance Lackey
Facility Engineer (HVAC)
Brewery Packaging Operator
Staff Brewer
Brewery QA Supervisor
Unemployed
Quality Supervisor (Manufacturing)
Quality Manager for an entire region
Quality Assurance Manager for an entire corporation
Pets
Boone the Dog in 2000, died 2001 (hit by car)
Cash the Dog in 2001, died 2014 (natural causes)
Barley the Dog in 2014, died 2015 (bad reaction to anesthesia during neutering)
I’m a newbie (joined in Dec 2014), but since then I have had the joy of welcoming my first grandchild into the world. 
Joined in 2003.
Got divorced.
Remarried.
Quit the part-timing as a deputy.
My dad died. Badly.
I got transferred from teaching high school to teaching 7th grade.
I had a stroke. (This may be related to the previous entry).
I no longer care much about a lot of things that used to be important to me.
Got my Ph.D.
Did a post-doc.
I have lived in three states.
I’ve moved four times.
Lost my religion.
Survived depression, came out on the other side to self-acceptance.
I joined March 2002.
Since joining in 1999, I have not really had many life altering changes. I am still doing the same job, albeit at a much higher level of technology. My children are now the kind of adults with which we enjoy spending time. We still live in the same house which will be paid off in eleven more payments. A little over three years ago I had a mild heart attack that was pretty scary.
Since 2003 the bigger items look like this …[ul][li]Laid off from life’s career / calling at age 45 with slim re-employment options in the same career.[]Started a successful company in a different industry.[]Sold the by then 50-employee company. Yaay! More Ka-ching than KAA-CHIIING!!!. Darn.[]Became un-laid off from old career.[]Made a boatload of money off the crash of 2008. Yaay![]Lost a boatload of money off the recovery of 2009. Dang![]Moved across the country with a one-year stopover along the way.[]Mom died suddenly. Crap.[]Wife had a metastatic return of long-dormant cancer which she handily beat. Whew![]Got serious about diet, exercise, and stress management for my own health. Yaay me.[]Replaced both cars. BFD.[*]Wife is having an advanced metastatic recurrence which came within a few days of killing her. Against the odds she’s since fought back to almost normal. Three cheers for modern medicine! But no way to know how long this good news will last. Holy Shit Batman! :eek:[/ul][/li]
All in all it’s been a busy 12 years.
The next 12 years will see me retire, SIL move across the country to near here, nearby MIL almost certainly expire of old age, and perhaps my wife lose the fourth or fifth round of her fight. All in all there’s more ways for things to go wrong than right. Waah! 
It’s not just since I joined the Dope, but this is the biggest change that’s ever happened in my life. I’m the survivor of a very rare cancer. Only one in a million people get it.
I joined the old AOL board in 1997 when I was a social worker, temporarily serving as Acting Assistant Director in the final weeks before our agency was going to be closing up shop. I had acquired my MSW in 1991 and had been working at this job, my one and only professional job, since 1993. I was earning $30K / yr up from the $25K I’d been pulling as a regular case worker. And prior to this job I had never earned more than $10K in any given year so having a “real job” was a very new experience for me. This was comparatively late in life (I was 38); I was surprised to find myself actually gainfully employed. I was already starting to refer to myself as middle-aged.
What I had been doing in the years prior to being a social worker was attempting to join up with the radical feminist movement. I’d come to the realization at age 21 in 1980 that I was differently gendered, and I found, in radical feminist theory, the words and ideas with which to explain most of that. So I’d majored in women’s studies as an undergrad and then gone on to try to pursue that in grad school. But by the early 1990s, feminism in academia was pretty heavily geared towards identity politics in a fashion that didn’t leave much room for a male person who wanted to question patriarchal norms within the same framework. In my final years as a grad student I got a theoretical article published which put my primary ideas into print, but then I needed income and pretty quickly drifted away from my unfinished PhD attempt. During my years as a social worker I experimented with “self publishing”, 1990s style, putting my best papers on my own personal web site and pasting my web URL into those search engines that existed at the time so my site would come up in searches.
Never worked in social work again. My income has been as a FileMaker Pro database developer since 1998.
Circa 2015, some things have come full circle: I again got immersed in trying to be socially active around my gender identity, this time not using feminist theory as my jumping-off point but rather approaching it from gender theory and queer theory, as (ironically enough) identity politics. I’m 56 (still middle-aged), thorougly accustomed to pulling down a professional salary, back to reading and writing and arguing theory with people…
… and still posting on the Dope!
Yeah, but what have you done lately?