The cascading effects of climate change.
Climate change itself is bad enough, if you’re one unlucky millions who will be displaced, killed or will otherwise suffer direct impacts.
It also has the potential to cause far-reaching harms that trigger other ‘biggest things’ mentioned in this thread.
(Before moving on, please note the word ‘potential’.)
Consider a small shift in regional temperature and rainfall patterns away from current food production areas. It is far from a given that other geographic areas will become crop-friendly to compensate, or that even if they did, the the new areas of cultivation could ramp up production in time to prevent mass food shortages.
Further, these shifts may take place under times of severe economic stress. A country that has just had major seaports and cities inundated by storm surges may not be in the position to develop new croplands or crop technologies.
Water rights and usage are tightly related areas of concern–even if limited to exacerbating the incidence in drought-prone areas, food security and human subsistence needs over vast areas will be threatened. This will take place against a backdrop of pre-existing water issues, whether from rapidly depleting aquifers to tensions over use (crops v. humans) to cross-border tensions.
Other climate change impacts will have similar wide-scale effects and will begin to have noticeable consequences while adaptation resources are severely strained. For example, consider a disease vector that reaches into an area that had previously reached apparent homoeostasis to a particular average amount of rainfall, and area that lacks a substantial infrastructure to manage or stand up to the increased rainfall.
With just that in mind, consider how climate change will intersect with many other ideas brought up in the thread.
If climate change effects become particularly acute, it is very likely that mitigation efforts will be given a high priority. One rationale for taking early action was how much cheaper it would have been had we begun earlier. Consider just the combination of an increased urgency (and hence political will) to do something combined with the increased need to reduce or sink emissions. The resulting sharp increases in energy cost (partially offset by advances in non-carbon technologies) will arrive concurrently with the other above-mentioned effects.
Poor, hungry, thirsty, energy-starved countries go to war. War begets war.