What's the most difficult room to break into in the world?

Mushroom?

Been there.

I’ll go with Kim Jong Un’s bedroom.

Level 5 Biohazard rooms.

The room where Microsoft keeps the codes to Windows. Another would be where Coke keeps its formula.

If James Cameron wanted to go there he could.

That’s actually a good way to think about the question posed in this thread. “Could James Cameron (or anyone with basically unlimited resources and access to people) get in?”

He could get in to the oval office by donating enough money to Obama’s campaign and arranging a meeting. He could get in to the Titanic by financing a diving expedition. He probably could not get in to Fort Knox or other sorts of facilities, though.

I’d like to think so, or at least hope so.

This makes me wonder - how easy would it be to break into the International Space Station in general? Obviously the most significant cost would be getting TO its location. But suppose you had a spaceship capable of reaching it but the station denies you clearance to dock. Could you force your way into an airlock without destroying the station? Does the ISS have anti-spaceship weapons mounted on it that could blast an invader from a distance?

Physical access to datacenters is usually secured with an eye to keeping out other employees who would accidentally wreck stuff rather than surviving an assault. I doubt that the NSA’s server room is much harder to get into than any of their other secured areas. It could possibly be easier, since there’s lots of equipment in a server room that needs attention from outside maintenance folk, and therefore more chances to insert an imposter.

You’d have difficulty getting it to… Open the pod bay doors.

The ISS doesn’t have any weapons – well, of course, they’d never publicly admit it, eh?

If you don’t care what condition it’s in, just drill a few holes, and yank out a slab of hull. The small holes let the pressure out gently; the big hole lets you get in. The crew dies horribly. You win.

If you want to capture the crew alive, it wouldn’t be too awfully hard to fabricate an intrusion airlock, something that would clamp on to a surface and seal it up tight, so you could then burn your way in. If you can build an assault spaceship, you can certainly go the extra few percent and build as assault lock. It wouldn’t be guaranteed to work, however; leaks are pretty likely.

If you mean the source code, definitely not, since it’s been leaked before, it’s probably just (copied many times over) onto some racked servers in data centers around the world, and they in fact share it with certain companies, academics, and governments. The Windows source code is protected by copyright and Windows will probably not be a commercial product for long enough to worry about any copyright protection ever expiring.

Probably some crazy-ass place within Pyongyang, North Korea, or wherever Kim Jong-un carries out the unrelenting militant dictatorship—if not their side of the JSA itself.