Why are drugs so hard to make and take so long to come out on the market?

Some of those aren’t diseases. “Liver failure” for instance can be caused by hundreds of things. And they’re progressing on the diabetes and multiple sclerosis fronts. Although I suspect that when your list is mostly taken care of you’ll be complaining that science can’t cure the disease of a shotgun blast to the head.

Leaps and bounds have also been made in medicating depression and anxiety. We can’t cure them - and the medications don’t always work - but fewer people suffer.

And, of course, there is Viagra. What would we have done without that?

You asked about diseases. None of these are diseases and all have had major improvements in treatment in the past 20 years. There are dozens of causes for each of these and dozens of lines of research on them.

Some of these have multiple causes, and all have improved treatments.

To sum up, you haven’t explained what you’re complaining about and you seem intent on ignoring all evidence presented to you. And you keep moving the goal posts. Pick a single point, explain your problem, and listen to the answers you are being given. This is getting tiresome.

I’m saying I don’t know any disease where there is cure or any drug or treatment that heals the body or tells the body to heal it self.

Not sure what you mean by many causes that cause.

-liver failure
-kidney failure
-Parkinson
-spinal cord injury
-diabetes
-stroke patients
-Multiple sclerosis
-neuron disease
-autoimmune disease and MS

When is the Emergency Medical Holographic program coming online? That should help.

I don’t think there’s much point in going through the rest of the list until you acknowledge that your premise is incorrect and misguided.

You’ve already demonstrated that your knowledge of medicine and biology is fairly limited, so I don’t think your expertise qualifies you to make any statements like this. Nearly everything you’ve said in this thread is wrong.

So what? These things caused liver failure , now you got liver failure but there no cure all we can do is treatment to slow it down.

You said and others have said it in the start of thread many reason why it takes a long time to make drug and it is complex and well yes I probably will not understand this in message board.

And like other poster said in similar thread the lock and key analogy they use in high school is not how it works. It not like Hollywood movies or what you learn in high school that cancer, bacteria ,virus and disease , set problem you find marker on it and make drug that binds to it and problem gone.That it is much more complex and affects many other areas of the body.That the lock and key analogy is way over simplified.

I get that.That it is very complex and with out college or university of taking class how drugs are made you will never really understand how complex it is.
But has public stand point comparing to many other things I understand the frustration and conspiracy theories going around.

And that if you a scientist ,doctor or in school it is taken has insult why so slow.But when it comes to many other things science and technology is changing very fast.

When it comes to medicine it is much slower than other things.

This list even if it was possible to have cure for all 9 of it in 100 years from now is slow comparing it to science and technology today.

-liver failure
-kidney failure
-Parkinson
-spinal cord injury
-diabetes
-stroke patients
-Multiple sclerosis
-neuron disease
-autoimmune disease and MS

But even still it does not look like there will be cure for all 9 of it in 100 years from now because for that to happen there would have to be one cure every 10 years.

I think if these things turn out to be 150 to that say 200 years for cure there would be public out cry.

May be the public is expecting too much or there is a communication problem with scientist and doctors and the media.

Tell me where 95% population understand any science other than terrible junk science you learn in high school where most are lucky to remember that.

And oh some things like being in construction ,trade ,firefighter ,computer tech and so on:eek::eek::eek: reading a good book not a junk book is not enough , you need work experience or volunteer to really understand it.

I don’t think anyone here other than scientist ,doctor or in school not high school I mean real school like college or university taking drug design ,human body ,chemistry and biology would understand the complexity of making a new drug or cure for such a problem.

Only thing the public can do is call you your congressman and senators for more money into medical research.

And the only thing scientist and doctors can do is speak out in public that these things are complex and it will be well over 100 years for cure for 9 things I talked about.

Since you continue to post things that have been demonstrated to you to be false there’s really no point continuing the discussion. When you decide you want to learn something from your threads then I’ll engage with you again.

In the meantime you can go right on complaining why we don’t have Star Trek medicine, flying cars, and jet packs, I’m out.

What things proven false? Only thing you are doing is babbling on and on about some things here in the list.

-liver failure
-kidney failure
-Parkinson
-spinal cord injury
-diabetes
-stroke patients
-Multiple sclerosis
-neuron disease
-autoimmune disease and MS
Has many causes. No where are you elaborating on this front.

Hepatitis B
Hepatitis C
Long term alcohol consumption
Cirrhosis
Hemochromatosis (an inherited disorder that causes the body to absorb and store too much iron)
Malnutrition

The causes of acute liver failure, when the liver fails rapidly, however, are often different. These include:

Acetaminophen (Tylenol) overdose.
Viruses including hepatitis A, B, and C (especially in children).
Reactions to certain prescription and herbal medications.
Ingestion of poisonous wild mushrooms.

kidney failure

I’m beginning to see this as a translation problem, not a medical problem…

sweat209, do you understand the definition of disease? For example, hepatitis and cirrhosis are diseases. Liver failure is a condition caused by these diseases. Liver failure can also be caused by other conditions that are not diseases, such as a drug overdose or malnutrition.

I ask this very basic question because it appears you are confusing diseases, which often have specific cures or treatments, with conditions, which can have multiple causes and treatments. You have said that there are very few cures for diseases, and many posters have proven that wrong. Now you are complaining that many conditions have not been cured, but if you consider that for a moment, you’ll realize that a condition doesn’t have a single cure.

Or are you asking when will we have a way for the body to regenerate itself? Are you waiting for a pill that can make a liver shed its damaged cells and regrow healthy tissue? Gene therapists and stem cell researchers are working on this problem, with some success so far. Do you want an artificial liver, or one grown in a lab? These are also being researched. So what exactly do you want?

Okay I don’t know in college or university what they call diseases means. I thought a diseases is when you body does some thing it should not like in diabetes ,parkinson ,liver failure and autoimmune.

Where infection is outside source so not really a diseases. And well cancer sorta of like a diseases.

Okay may be this is where we are having a hard time communicating where in college or university is very define what it is.

So out of list I posted what would be a diseases and the others not diseases what would it be called.

So you saying liver failure and kidney failure is not a diseases?And has many causes? Even if the cause stops you still have damage to the liver or kidney. So than this is two problems. Stop the causes and heal the liver or kidney or tell the body to heal it self.

Take one drug to stop the cause and other drug to heal the liver or kidney . If this is what you are trying to say.

Exactly, this is what I meant.

Like I mentioned, some causes can’t be treated with drugs. To continue with the example, if a patient suffers from liver failure caused by malnourishment, I don’t believe there is much a doctor can do except tell the patient to eat properly. (I am not a doctor, there may be other treatment.) But if the patient has a form of hepatitis, the doctor can prescribe drugs. These are drugs that were developed to treat those specific diseases.

Sometimes diseases and conditions get confused. For example, years ago doctors couldn’t do much for patients with stomach ulcers. They prescribed rest and maybe some antacids. Then researchers discovered that some ulcers were caused by bacteria, and soon after drugs were developed that could cure ulcers. So medicine does move forward.

As for drugs to actually make the damaged organ heal or regrow… A medical professional could answer that question better than me. To my knowledge, drugs can encourage organs to heal themselves. I myself take steroids to help my asthmatic lungs heal themselves. Anti-inflammatories help damaged skin heal itself. So it is possible.

You are confusing finding a compound which can treat/cure a disease with getting it approved for use.

As stated by others, your fixation on computers is irrelevant. The use of computers in modeling and “rational drug design” was supposed to revolutionize medicinal chemistry, much like genomics was going to answer all biochemical questions, and, when that didn’t pan out, metabolomics.

It’s easy to come up with compounds that will fit an active site in a critical enzyme and bind tightly. That doesn’t automatically make it a viable drug, because that compound will also interact with the myriad of other enzymes with unknown consequences, will be metabolized into compounds with unknown biological consequences, and may not have the right physico-chemical properties needed to make the molecule “druggable.”

Computers can predict only so much; the FDA wants data, not probabilities, and for that, you have to kick it old-school. Phase 1 safety data. Phase 2 efficacy and dosage studies, and Phase 3 clinical trials.

And of course, you have to have toxicological data; Administration/disposition/metabolism/excretion data on several different species. You have to identify and quantitate everything in your drug product that is present at more than 0.1% of the total. You have to demonstrate that your drug is stable in its final form over a range of storage conditions. You have to have “good laboratory practices” in place, including protocols, quality assurance and quality control. You have to develop a formulation that is stable, and can guarantee a specific dose.

None of these things (or the many many other considerations I neglected to mention) are easy or fast or cheap, and if you cut corners, people can die, and you can go to prison.

There is no conspiracy. Drug development is a difficult enough process when you have a know mechanism of disease. MS and other diseases of unknown etiology are that much harder.

Here’s the thing, sweat209: scientists and doctors aren’t actually wizards.

For what it’s worth, Hepatitis C has all but been cured; new treatments have come out in the past two years reduce viral load to undetectable levels and keep them there for over 90% of patients. This is leaps and bounds better than previous treatments. True, it took a long time to develop, but here we are.

Cite??

I don’t think no one thinks doctors are wizards.:eek::eek: I’m sure most people would love if they where.:eek::eek:
After reading some of posts here , I think understand what some of the members are trying to say to me that medical progressive from 1900 to now and new stuff they are working on is not so apparent to public with out being in the know example.

-liver failure
-kidney failure

Being a condition not a disease.So like the posters saying above there are many diseases that can cause liver failure and kidney failure and we can treat some of that.So it gets over looked .

What shows up in popular science and media is more wow factor!! we have cure for x,x,x,x,x condition. So if this condition you have could be caused by x,x,x or x and there is different types of x don’t make it to popular science and media . I can see why some of us look at it like nothing as changed.

Like other threads here saying cars and planes from 60’s to now have not really changed much. But under the hood it is like day and night.So not apparent to the public.

I’m not sure if Multiple sclerosis or neuron disease is condition or a disease or if there are different types of Multiple sclerosis or neuron disease . I’m not sure if they even know want what causes it

Speaking of wizards , I wonder how ready the US is for new epidemic some thing like Polio ,Smallpox or Spanish flu or Biowarfare.

And how long before cure or they could get it under control. One of these days some thing new like this will come along.