The liver size isn’t as much a factor as the function. In fact, an especially large liver is more likely to be diseased, making the toxic dose lower than in a normal (sized) liver.
Liver failure is a truly terrible way to die. Vlad/Igor is incorrect in saying when liver cells die you will too.
It can take weeks to die from liver failure. As the liver fails, toxins build up in the blood, causing shaking tremors, confusion, restlessness and massive swelling of the abdomen. The skin becomes yellow/orange, from the accumulation of bilirubin. Since the liver makes several of the components required for blood clotting, bleeding from the bowel becomes problematic. Ultimately every needle stick, every tiny trauma becomes a bleeding crisis.
The restlessness and confusion is an early stage of hepatic coma. It will eventually progress to unconsciousness, and finally, the blessed release of death.
The only treatment, other than liver transplant, is supportive. Examples of supportive care are, replacing the lost blood products and restraints to prevent injury from the restlessness.
Liver transplant isn’t always an option, since many patients die before a compatible donor comes along.
The surgery is complicated. It can take 8 hours to complete. When the patient comes back from surgery, they require tons of blood components. They can ooze for days. They are in ICU for days to weeks after surgery.
If the transplant is successful, the patient has to take anti-rejection drugs for the rest of his life. He can never drink alcohol again. He must be careful to not be exposed to contagious disease, since the anti-rejection drugs compromise the immune system.