There was a Colflesh Funeral Parlor in suburban Philadelphia when I was growing up.
This place has been mentioned elsewhere on the SDMB in the past: Here in Lexington Kentucky we have a company called **Big Ass Fans **. It is a real, and apparenly quite successful, industrial-strength fan company. They have their logo (follow the link above) writ large on the side of their building. This caused an uproar until someone pointed out that this business was in the middle of all the local strip joints…
There’s an Atlasta Motel on I-70 between KC and St Louis.
Bunns is a strip joint in Independence, MO. Ooops, “Gentlemen’s Club”.
Kum and Go is a regional gas station/convenience store.
Somewhere in western Kansas or eastern Colorado is a vet’s office called “Steve’s Dog anf Cat Repair.”
Adrian, MI - Pizza Bucket. And they didn’t just offer pizza - they also had frog legs.
I was a poor college student, but I was still too terrified to eat there. Dorm food was preferable.
In Salem MA, there is a liquore store chain called The Bunghole. And in Vernon, CT, on Rte 83, there’s a fried chicken place called Lik-a-Chick.
That’s fantastic! I must get the mug. It would be the talk of the office. 
There was a restaurant that my school bus used to drive by that had a huge sign that wrapped around that said (on the front) “Git-Yo Chicken, Fish &” (on the side) “Burgers.” I never ate there, but I heard people call it “Git-Yo Chicken.” There used to be a picture of it on collagehumor.com, but now I can’t find it.
My ex-roomie used to work at Filthy McNasty’s, home of the 20 foot wood. It’s in Edmonton though.
Doggie Style - a pet grooming service
That’s all I can think of off the top of my head.
We have a convenience store nearby called The Dixie Chigger. Or did, anyway; I think it’s under new management now, and they changed the name.
Out on the edge of town we used to have a one-stop shopping extravaganza advertising “Live Bait, Antiques, and Haircuts.”
There is (or was, last time I was there) one on the outskirts Bishop’s Falls, Newfoundland, too. Wait…I think it’s Bishop’s…maybe it was near Gander…No, I’m pretty sure it’s Bishop’s… Will have to check when I go home next month if it’s still there.
I’ve always been amused by the store Lovecraft, which sells…marital aids.
My orthodontists were Drs. Hammer and Hook. Not exactly a business name but funny.
We used to have a restaurant called Murder Burger. Damned funny in a town that’s heavily veggitarian/vegan/holistic. But, they wussed out and changed it to Redrum Burger. More family friendly, or some crap.
There’s a home health care/hospice business in this area that is called ‘Almost Angels.’ How tacky is that?!
Yep. That gets an 8 on the creepy scale.
Quite right, FilmGeek… But how could you forget The Outhouse, located just on the west side of Lawrence? BYOB, btw.
There used to be a hip beauty/barber shop a few miles east of Bunns called Knuckleheads.
Tattoo shops in Independence: Kingpin (where I got my first tat) and Purgatory
Famous ink shop in KC: Grimm’s Tattoo
Small fast food chicken chain, mostly in KCK: Go Chicken Go (best damn livers & gizzards on earth)
Bars in and around KC:
Velvet Dog
The Quaff (worst Long Island Iced Tea)
The Tool Shed (appropriately named, considering their clientele)
Rat Hole Tavern
Chinese Restaurants:
Ho House (no longer exists, sadly enough)
Fookee Chinese Buffet
And I have to mention the Bank of Tightwad, in Tightwad MO. Too bad they were bought by United Missouri Bank. I always got a kick out of driving past it… 
Where I used to live, in southern Ohio (well, a different part of it) we had a store called McArthur Automotive and Florist but I don’t think they sold too many flowers at first, and most people didn’t get their cars fixed there…
I think they are still in business though, those lucky people…
We’ve got a hot dog joint called “Eat It ‘n’ Beat it”
A computer repair shop called “Byte Me”
Try the Cthulhu Tickler!
I pass this all the time. For the record, “bunghole” is the opening in a keg or cask where you get the contents out. It’s a legit and appropriate word, although people attribute other meanings to the word.
I’ve seen Cluck U Chicken.
There’s a hairdressers round here called Hair Force One, and I passed a floor shop in Birmingham the other day called Plus Floors, which isn’t funny till you say it out loud.
I wonder how you buy floors?
There’s a signmaking company in Allston, MA, called Jim Did It. Good name - “Where’d you get that sign made?” “Jim Did It.”
There used to be the Dippin’ Donuts & Police Supply in Dorchester. Alas, they closed a while back.
I have said “Plus Floors” aloud about ten times now and I don’t get it. 