Atoms (or electrons, for that matter) are not tiny classical balls. Atoms “bounce off each other” due to mutual repulsion of their orbiting electrons, generally at much greater distances than we imagine. The orbiting positrons (anti-electrons) of anti-helium would be attracted to the orbiting electrons of any nearby “normal” atom with a ferocity unseen since the Sadie Hawkins Dance. Since nothing prevents them from “coming into contact” (substantially overlapping their waveforms), the positron-electron attraction between interacting atoms and anti-atoms would vastly overwhelm their attraction to their respective nuclei, which are a substantial distance from the orbitals, for quantum reason (good thing - or atoms wouldn’t be stable).
The orbiting positrons (and electrons) would strip from their nuclei almost instantly, and mutually annihilate (convert to a pair of 511 keV gamma rays). The naked nuclei, hampered by their greater inertia, would lag slightly behind behind, because they don’t have quite as favorable a charge/mass ratio - the attractive force ‘felt’ by a Helium nucleus (2n+2p) is only twice that of an electron, but it has almost 8000 times the inertia to overcome. Of course, when it does finally annihilate a micro-jiffy later, it will release 8000 times the energy, in gamma rays that are individually 2000 times as powerful as the ones the electrons gave off.
Several grams of antimatter, regardless of element, is effectively a small nuke. The trickiest part of building an A-bomb are containment and confinement - you need to keep the bomb together long enough for the chain reaction to proceed far enough for a good yield. (A critical mass of an isotope, sitting on a table, will only undergo enough chain reaction to vaporize in a brief messy burst of raditation and vaporized istope that falls far short of an atom bomb.)
The powerful charge attraction anti-particle pairs overcomes that problem easily, and -more importantly- antimatter doesn’t have to be confined to “detonate”. Since antimatter reacts directly and instantly, rather than “positive feedback” chain reaction, it doesn’t matter if it gets scattered by the blast of the first atoms, it will still react with normal matter 100% within some tiny fraction of a second.
Only a fraction of an atom bomb undergoes rapid fission, and only a tiny fraction of the fission products are pure energy, but with antimatter, 100% converts to pure energy. The energy yield is actually 200%, since an equivalent mass of oridinary matter in the air (which we often ignore) will also be converted to energy. [It’s like jets vs. rockets: jets don’t count the air around them as ‘fuel’ but rockets must being their own oxidizer. If you’re doing particle experiments or envisioning a space battle, don’t forget the matter side of the equation.]
A kiloton is 4.2 x 10^12 J. 1 gram of antimatter reacts with one gram of matter to produce 1.8 x 10^14 J (42.85 kT). A 1 megaton bomb is the equivalent of allowing 23.35 g (.82 oz) of antimatter to react with matter.
Don’t do this at home, kiddies