My FN Browning Hi-Power came with an ambi safety, and is one of the most ergonomic and naturally pointing semi-autos I’ve tried. I prefer narrower grips, which reduces trigger jerk for me, and the hi-power is one of the few (well, the only one I’ve tried so far) double-stack guns that I’m quite comfortable with. Plus, they’re available in both 9mm and .40. I should mention that the .40 version has been re-designed almost from the ground up to handle the .40 pressures, and is not just a modified 9mm.
Best way for you to chose, however, is to try them yourself, if it is at all possible for you.
ETA: Woops, this is really **trupa **talking. Our computer was still logged in to my better half’s account. Sorry.