I’ve done beef, as well as tilapia jerky, using a dehydrator.
For beef, I normally use london broil, because it’s normally a cheaper cut. Flank and sirloin were normally 6.99/lb or more prior to supply chain issues, while london broil would be 4.99 or so, sometimes on sale for less. It is chewier, and less ‘beefy’ for me, but it gets the job done and doesn’t require a ton of trimming. I’d get it about 2/3 frozen, then slice thin on the bias before the marinade.
I have two main marinades, one is a mix of soy sauce, a hit of liquid smoke, dark brown sugar, garlic, and red pepper flake [ for the sweet spicy and smoky taste ]. My second is my homemade salsa which is nothing but jalapenos, onions, lime, salt, with a small tomato for extra fluid and an extra habanero for some extra heat, although if you’re in a hurry 505 brand Roasted Green Chiles plus a bit of extra lime works well.
Either way, I get a jerky I’m happy with, but yeah, I figure by mass I’m sitting around 1/3 to 1/2 “loss”, which is honestly just water. Still much cheaper than any equivalent all beef jerky in the store. So it’s certainly a special occasion when I make a batch. I tend to keep it in a paper bag in the pantry, which allows it to loose a little bit of the moisture as time goes on, rather than a plastic bag that might get some condensation. And it never lasts long enough for me to worry about spoilage. 
As for Tilapia, I was trying it because fish is muuuuuch cheaper than beef, and oftimes healthier, and figured with a strong marinade, it shouldn’t be too bad. And the answer was, it wasn’t. But dehydrating certainly concentrated the fishiness, to the point that even a 48 hour soak wasn’t giving me the flavor I wanted. And it tended to dry super hard and chewy, more so than I was happy with. So I chocked it up to not being worth the time and money. I have considered doing it again with salmon, but at price for a decent fillet, figure I might as well make beef.