Are caloric restriction and/or alternate day fasting verified as effective in humans

I have heard of animal studies on caloric restriction (60-70% of maintenance) or alternate day fasting (eat what you want one day, eat 0-30% of maintenance the next) are effective at chronic disease prevention.

Do they work to treat or mitigate existing chronic diseases or just as preventative measures?

What about alternate day caloric restriction, eat 100% of maintenance one day, then 60% the next. Does that work or do you need to go down to 20% of maintenance on alternating days? Doing 60-70% of maintenance seems easier to maintain long term.

Has anyone adopted one of these lifestyles to stave off diseases of old age?