Anecdotal, but I really do know several people who have lost significant amounts of weight and kept it off. Two are from my immediate family:
My mother was obese at one time when she was in her late 40s/early 50s, but while she never became a slim woman for the last 20 years of her life she was in the “extra pounds” range but not what anybody would describe as “really fat”- I’d estimate she weighed 250+ at her biggest and hovered in the ~200 range (which I’m not calling small, but incomparable to what she had been- plus she was about 5’10 [before the shrinking commenced] and had a large frame) from her mid-50s to early 70s. That was not following any particular diet but just eating less (her 40s/early 50s were miserable due to external circumstances and she became a comfort eater), and she had a fairly active lifestyle (no actual formal exercises except for some PT after a knee surgery, but her job kept her constantly walking).
The better example is my brother-in-law. He had Type 2 diabetes in his early 40s, and it was due to constant overeating; it didn’t help that (swear to Og) he owned an ice cream parlor. He weighed around 290 lbs.; he was about 6’3 and has a large frame, but that’s still a lot of extra weight. He had a major health scare unrelated to the diabetes when he was about 45, he was hospitalized during which time he lost about 30 pounds, and though he initially gained that back when he returned home from the hospital several factors convinced him to change his ways.
He initially lost down to about 250, at which point his blood sugar improved greatly. He roller coastered for a few months but then settled around 240-250 for a couple of years, then when his diabetes returned he went on a steady decrease/maintenance and is now currently around 215 pounds, which may sound heavy but is actually slim on him. It is strictly through diet (lots of greens, very little meat, extremely limited and rare sugar/bread/processed starch intake) and exercise (daily walk and lifts). It’s been ten years since he weighed 290 pounds and I would be very surprised if was ever up to anywhere near that again. The two things I attribute his success to are the initial health scare that made him start living healthier, and my sister (who is not and has never been fat) for giving him hell whenever he went off his diet or stopped exercising. (I have God knows how many differences with my sister, but I can say that I don’t think she’d care if he weighed 150 pounds or 400 as far as vanity goes, but she absolutely adores him and is not going to be a widow a minute earlier than she has to be.)
I have known others as well, including one friend who lost well over 100 pounds on Atkins (which is not that surprising) and has kept it off for a decade (which is statistically on par with winning top prize on a scratch-off [i.e. not the PowerBall, but still very very rare]).
I’ve always been heavy. Since I’ve been an adult my weight has gone from a low of 190 pounds (for a few minutes in the early '90s) to a high of just over 300 pounds (for a few weeks in the late '90s), but for the vast majority of the time it’s stayed within a 250-270 range since I was in high school. In a way that’s really cool, because now when I see people I went to high school with I’m usually the only one who can still fit into the clothes he wore then. (I live in Alabama, one of the most obese states in the nation, and there are many people who were skinny in high school and are now “just damn”.)
I’ve lost a lot of weight twice, once by lots of exercise and dietary changes (in my mid-20s) and once through Atkins. Both times I put it back on within months. It’s been a long time since I even tried to lose weight, but I’m ready and about to do some lifechanges. I’ve started by quitting smoking, and that encourages me somewhat; I loved smoking- loved it loved it loved it- and yet I’m totally honest when I say that after 6 months I really don’t even miss it and I’ve gotten to where I find the smell of stale cigarettes repulsive. I’ve worked in some moderate exercise (joined the Y, I’m not causing friction fires with my speed but I’m burning off a couple of thousand calories per week [cumulative, not per visit] on the treadmill and elliptical and swimming and what not) and I’ve lost about 5 pounds and hope to lose some more. (I currently have a “please give me suggestions for reading” thread on IMHO.) I’m surprisingly optimistic for somebody who’s not a natural optimist and it’s in part because I’m not starting off like gangbusters but just more of a stroll: I’m not in a great rush- it would be wonderful to lose 50 pounds by Christmas but it’s not really a goal- my goal is to look noticeably slimmer and feel better by then). I couldn’t give a damn about what my BMI is (I don’t pretend to be a fitness expert by any stretch but one core belief I do have is, if you’ll pardon me, “Fuck the BMI in its eye”- when I weighed 190 pounds you could see my ribs and people worried I had cancer or AIDS [really], but per the BMI I still had about 12 pounds to go). I’m mainly interested in having more energy and feeling good.
I already have noticeably more steam and endurance, so here’s hoping…