First, big mistake going anywhere near LA around Thanksgiving - day of, or day before. Easily the worst time for travel that direction. Christmas isn’t as bad, so you’re already in for a better time.
When I head north to go to the bay area, I always take I-15 to the 210. The 210 hugs the base of the mountains all the way around the LA basin, and then hooks into the I-5 just as it is climbing the hills. WAY better than staying on I-5 all the way, and significantly better than taking the 405 around the south/west side.
The other added benefit is that I-15 is 70 mph most of the way (up until Corona).
Leaving in the afternoon, you may hit some traffic on I-15 getting out of town (from Mira Mesa all the way up to Escondido). But from then on, it should be relatively smooth sailing. Even when you get near Corona/Norco (you’ll be going against all the commuter traffic leaving the city).
You can either stay on I-15 all the way to the 210 (north of the I-10/I-15 interchange). But I prefer to take the 60 west to the 57 (over the hills from Chino). You need to get off the freeway and go through a light to get from the 60 west to the 57 north, but not a big deal. Just pay attention to the signs as you descend down the hill from Chino Hills.
Looking at a map, you may be tempted to either:
A. take the 91 west, to the 71 north, to the 210
B. take the 60 west to the 71 north
C. take the I-10 west to the 57
or
D. stay on the I-15 all the way to the intersection with the 210
I have tried each of these options, and each has drawbacks:
A and B rely on the 71, and you hit a (very) slow, non-freeway section outside Pomona. Costs you time.
C puts you on a crappy (old, narrow) section of the I-10 from Ontario to Pomona, and this section is always slow.
D is the simplest, but you will notice that the I-15 veers east before hitting the 210. So you actually add some distance for the “simplicity”. Again, you will be going against traffic on the 210, so it won’t be too bad. But I hate adding any extra miles to a trip.
Especially since they added some lanes, the 60 is now the preferred way to get to the 57. The only annoying part is the little side-street detour you need to take to get to the 57 north. (Coming back, there is a similar detour to get from the 57 south to the 60 east).
If you miss this, you can stay on the 60 to the 605, and take that north to the 210 as well. But the section of the 60 from the 57 to the 605 generally slows down (for no apparent reason usually).
So to recap:
I-15 north (slow until Escondido, but good after that)
(past Norco) 60 west
(over the hill from Chino) 57 north
210 west
I-5 north
One last note: on the 210 near Pasadena where the 134 branches off, you will need to move to the far right lane to stay on the 210. The other 3 (4 ?) lanes become the 134 west). There will be signs, but just pay attention when you get to Pasadena.
If there is any slowing on the 210, it is usually in the Azusa/Pasadena area. But other than that, it usually moves pretty good.