I was all set to come in here with my list…Richard John Marcej made me rethink the concept of “worst”. I think we can all agree “Reply All” is an excellent example of horrible though…how does that thing has over 5,000 subscribers on GoComics?!?. (If you type “reply all comic is horrible” into Google, it comes back with “Did you mean: reply all comic is terrible”.)
Other comics end up on my “disappointment” list rather than my “worst” list. “We The Robots,” for example, looks like fun but has fallen hard into sticking with traditional, bland work/home humor. And I can’t stand to look at “Dilbert” anymore because Scott Adams has turned into an MRA clod.
I haven’t seen any mentions of “Scary Gary”…it’s not side-splittingly funny, but its absurdity is enjoyable. “Sarah’s Scribbles” is also a good one (though it tends to break the traditional comic format, so it might not count).