We see many cartoons and movies where some of the protagonists fight from GTLRs. Sometimes these can fly, and sometimes they have other capabilities.
I can easily imagine uses for small robots with any number of legs, all the way down to insect size. Larger robots would not do too badly with at least three legs for stability, and more to spread their weight.
For large robots, it seems to me that the combination of size and small number of support points would be a huge disadvantage: roads and any surface less strong that solid granite bedrocl would crumble under their weight.
My theory, then, is that the GTLRs are mostly actually used for psychological reasons: to impress and encourage allies, and intimidate enemies.
The exception mught be for specialised combat against individual large monsters, but even then, that would have a large psychological component. If the Navy, Air Forces, and Army could vanquish the monster, they would; only when the regular forces prove ineffective is the GTLR team called in.
The GTLR itself, I suspect, would be tailored to the psychology of the monster it is meant to fight, and is essentially a psychological tool as much as a physiucal combatant: a tool to convince the monster to cease ravaging the Metropolis and go away.
So…
Is there any tactical situation in which a Giant Two-Legged Robot (GTLR) would actually be an advantage?