The most obvious is that Presidential elections are suddenly very different, with the 55 electoral college votes from California no longer (almost) guaranteed to the the Democratic nominee. I’d imagine that you’d see much more campaigning in smaller states than you do now (although things may not be so different from what happens now, considering California has not gone to the Republican nominee since Reagan was running).
But what about other political effects? What are the consequences of California no longer being a factor in US politics?
What about the effects on US law? California currently plays a big part in 9th Circuit jurisprudence. Certainly you’d see the other districts (especially Washington and Alaska) playing a bigger role.