Can anyone help with this Simpson math-related lottery question?

In a classic Simpsons episode, Homer has 50 lottery tickets. When the first number is called, it is revealed that none of his 50 tickets has that number. Marge reminds him he can win something if he gets 5 of 6, but again, on the second number, none of his 50 cards has that number. Assuming the numbers used are the same as in Powerball, what is the formula for figuring out the odds of not getting any of 2 numbers on any of 50 tickets?

Help! I posted this twice by mistake- could a kindly mod please delete this one?

Duplicate thread.

I’mma just wandering by and thought I’d close this one-horse thread down.