Exactly what it says on the tin.
Bonus points: guess the classic SF works being parodied.
I’m not sure these are direct parodies of specific works, but rather treatments of some of the classic themes of SF.
Considering that the theme seems to be sort of “There are some things (Cave)Man was not meant to know”, it looks more like a parody of science fiction flicks, rather than of SF literature. Literature generally has a more optimistic view of applied science – it’s movies that have generally been afraid that Man Will Go Too Far.
(I used to argue that reading Science Fiction helps expand a person’s outlook, and allows us to examine our own situations from a different perspective. Then I realized that I was usually reading a book about creatures born from radioactive meatloaf that are threatening Chicago, and how a girl with ginormous boobs and a big gun has to stop them.)
I read that Shoe cartoon, too.
About thirty-five, forty years back. I had it on the door of my dorm.
I dunno, the last one reminds me a heck of a lot of a certain story, I forget the author but maybe Kuttner, about a transdimensional wormhole that is promptly put to good use as a garbage disposal. Guess how that turns out. 
He probably wasn’t the first, but Terry Pratchett used the wormhole toilet gag in The Last Continent.
Nope, that wasn’t the thing I was thinking of. Some short story where the aliens on the other side of the wormhole start throwing their trash at us in revenge, thus establishing First Contact. The story ends with the scientist-type protagonist swapping his dirty dishwater for the Xyzzygian equivalent of a dead cat, I think.
Ah, Dresden Codak. Dude’s got talent and a killer sense of humor.