Wile E. Coyote. No matter what he tries, all his schemes to catch the Road Runner invariably fail. 
Oh yeah, as far as 24 goes, let’s also not forget (ok, I’ll box Day Six spoilers):
Both his brother and father are traitors (being at least involved in the Day Five conspiracy at least inadvertently responsible for Day Six). Not only that, but his brother was killed by his father mere hours after he found out about their involvement.
I guess we’ll have to add Kenny from South Park as well.
Everyone on Gilligan’s island besides Gilligan.
Milburn Drysdale got shat on pretty regularly. I remember when he invested a bundle in Granny’s cold cure medicine. And the look on his face when she later explained, “Drink this here medicine, and in a week to ten days, your cold’ll be gone!”
Cordelia Chase of “Buffy” and "Angel’ had more than her share of bad luck. She got rebarred through the stomach, lost her home and her trust fund because of her parents’ tax fraud, got impregnated by demon spawn more than once, got duped by the Demon Skip, and suffered numerous other indignities too numerous to mention here.
Michael Douglas as Bill Foster (“De Fens”) in Falling Down:
[ul]
[li]Gets stuck in traffic[/li][li]Gets hassled by shop owner who won’t make change for the phone (this is 1993, before most of us carried a cell phone) without making a purchase. Shop owner sells soda for 85¢, not enough change for a phone call. Bill goes on massive tirade about inflated prices and destroys merchandise.[/li][li]Gets harrassed by gang members for being on their turf. Bill fights back and chases them off.[/li][li]Gang members try to retaliate by shooting at De-Fens, but missing, causing a lot of destruction elsewhere.[/li][li]Gets accosted by bum. Upon surrendering his suitcase, bum is disappointed ti find suitcase only contains a sandwich and an apple.[/li][li]Is denied service of breakfast at Whammy Burger, decides to order lunch. Thin hamburgers do not resemble picture on menu board.[/li][li]Gets hassled by pay phone user, shoots up phone booth so other guy can’t use it- it’s “out of order”.[/li][li]Goes into army/navy surplus store that turns out to be run by a bigoted, homophobic and militant racist Nazi who tries to befriend Bill for taking his stance against society and even helps hide him from the police, only to feel betrayed when Bill doesn’t agree with his racist views. Nazi tries to victimize Bill, who gets away by stabbing his agressor.[/li][li]Gets hassled by street construction worker who will not let Bill walk through the construction site. Bill disagrees with what he sees as a misuse of city funds, so he launches a missile into sewer and causes an explosion to give the guys “something to fix”.[/li][li]Cuts through private country club and gets yelled at by angry golfers who nearly hit him with a golf ball. Bill shoots golfer’s cart, which rolls into water. Golfer has heart attack and needs pills, which were in the cart.[/li][li]Confronted by police on pier. In act of suicicde-by-cop, Bill brandishes a toy water pistol, which causes the police to shoot him and make him fall off the pier into the water.[/li][/ul]
This all happened in the course of one day.
Yeh, I mean even when he comes up with the perfect foolproof plan, the laws of physics alter themselves just to thwart him!
Also, the land dwellers refuse to even recognize Atlantis’ existance, because that would call into doubt the international status of the open ocean and because they would have to stop polluting and despoiling the ocean. And now Aquaman’s on the outs with the closest thing he ever had to friends, the Justice League, because they defend the status quo.
That was karma, man. Remember how cruel she was to other people at the high school?
Hans Moleman
Everytime the dude is seen he is on the verge of another calamity. How many times has he died anyway?
Lucky, from “Stunt Dawgs” - except on Friday the 13th. And Donald Duck (not that he doesn’t deserve it).
You forgot trapped in a burning house with a hornt lesbian.
Jenny Garth, who played Kelly, has said a bunch of times in interviews that she told the writers to make her character a total punching bag. Rape her, burn her, shoot her, hook her on junk, all good.
I know! I always thought that was awesome of her. She seemed to really get the point of the show, which was: hilarious melodrama.
I choose me!
Well, as I said, at the moment he’s dead, and Atlantis has been reduced to rubble and a handful of aquatic Bronze-Age states.
Ken Pile. His only crimes were to love a woman and love animals. Oh, and rob a bank and attempt murder. The woman slept with everyone but him. The three times he tried to kill a witness, he killed one of her dogs. All of his pet fish were eaten in front of him, while he was tied to a chair with french fries stuck up his nose.
Sean Penn’s character in U-Turn. He really can’t catch a break.
If you want to distill it to one character, I’d pick Mark Greene.
Wife leaves him.
He loses his job to Kerrie Weaver.
Suffers one of the most horrific butt-kickings ever on network TV.
Performs the most disastrous baby delivery…EVER!
Continuing problems with his daughter.
Finally finds love and some measure of stability.
And dies from a brain tumor.
The only thing missing was drug addiction (they gave that one to Carter) or he would have been right up there with David Morse.
Also, it was discovered he got his MD from a diploma mill, and had to spend hours a day for months taking make-up classes while still working long hours as a resident.
And then his second wife left him, ostensibly to go back home to wherever they were from, but really because the actress who played her got a job on thirtysomething.
Bumblebee Man, also on The Simpsons.
every single character Ben Stiller has ever played.
Hurley from Lost, as has been noted by himself.
Batman’s witnessed the death of his parents and two of his sidekicks (if Stephanie Brown counts), gets framed for murder by Lex Luthor, gets brainwashed by Zatanna…