As in Deeeeeeeeeeeetroit! The Dee. 
A bit more clarifization: The GAR in hi-GAR-ra is pronounced to rhyme with pare or ware, not jar or tar. So it’s “high GARE uh” or occasionally “hee GARE uh”
As for San PAB-lo: Taking this a step farther: “San” is pronounced wrong too, rhyming with the English man, tan, pan. And not just in San Pablo, but in San Francisco and everywhere from San Diego and San Antonio to San Rafael and wherever. Ditto for cities with “Santa”.
How the fuck else would you pronounce “San” in English? I went to a dozen online audio pronunciation guides and they all said “San” to rime with man, including site where exactly that wording was given. Now yes, in Spanish the pronunciation is more like “sun” , but that’s accent. So, it’s not ‘wrong”.
unless your like me and marilyn monroe from busstop and you say “CANS CITY”
sloppy I know.
I pronounce it “Bob.”
I see what you did there.
Houston is either Houston or H-town. Occassionally the news or sports refer to “the Bayou City”, but that isn’t common in parlance. I might say “downtown” for going into Houston from the burbs.
As a San Franciscan with friends in Oakland, I’ve heard Oaktown a lot, but I’m not sure how much of that is joking. Also, nobody in Berkeley calls it Berzerkely, or the People’s Republic of Berkeley. Not sure if they did in the 60s, but not now.
Yeah, that’s SLO’s Chinatown. It’s a California Historical Landmark. It’s kind of like Santa Barbara’s Chinatown, which consists of the old shell of Jimmy’s Oriental Gardens, a bar with strong drinks which sadly closed about 5 years ago.
Looking him up, there’s a pretty cool anecdote:
Reminds me of the joke about what would happen if a nuclear weapon was ever detonated in New York City (The Boston Herald’s headline would read “Hub man injured in NYC Blast”)
I like to refer to Reno, NV as “the biggest little shit-hole in the west,” but it never seemed to catch on.
That is, if you’re not afraid of being sued by Denise Whiting, hon.
Also in Boston, a slightly hip portmanteau is “Camberville” to refer to the pair of cities just this side of the river (Cambridge and Somerville). The joke nickname “The People’s Republic of Cambridge” (often simply “The People’s Republic”) is used often enough too.
I’ve heard Toronto called Hogtown about as frequently as I’ve heard it called The Big Smoke, Muddy York or Toronto the Good (i.e., almost never).
Seconded.
A few French ones:
Parisians often call Paris “Paname”, but I’m not sure anyone who’s *not *a resident does. It’s also called “la ville lumière” (the city of light) but mostly only by tour guides and the PR office 
People from Marseilles will sometimes call it by its Occitan name, Massilia - but the rest of France doesn’t to the best of my knowledge. It is also called “la cité Phocéenne” (the Phocean city), from the name of the place the Greeks who founded the city hailed from.
Toulouse is often called “the pink city” by residents and outsiders alike (because most of its historical buildings are built out of naked bricks).
And an obscure one: the city I grew up in was usually referred to by its initials, BLR - because the full name, “Bourg la Reine” (lit. Queen Burrough) sounds exactly like “Penetrate the Queen”.
Which in and of itself wouldn’t be that bad, except when asking someone if he lives there. The full phrase would then be “t’habites Bourg la Reine ?”, which sounds exactly like “Does your dick penetrate the queen ?”
Missoula (Montana) is sometimes locally referred to as “Zoo Town”, though in my experience by more recent arrivals (e.g. college students and other transients) moreso than long-time residents.
Phoenix is called the Valley of the Sun. It is common to refer to it as The Valley.
Great summary, to which I’d just add: anything north of Yonkers or in Connecticut is “the Country.”
For 20 minutes.
somebody had to say it
Portland is often referred to as Stumptown, Bridgetown or Beervana. Also occasionally as PDX, the airport designator.
By the way, my wife shrieked in pain at the mere suggestion of “Frisco”. She lived there for 25 years.