My Dad is a fifth generation San Franciscan, and he will call it Frisco. The rich people and Herb Caen disapprove.
Could be, but I’ve never heard this term before. If we define a nickname as a name that people use as short hand for something else that they could use in casual company without making waves, then Seattle doesn’t have one.
I’ve heard more than a few ‘natives’ of New Orleans refer to it as “N.O.”.
Born and raised in Houston (the Heights/North Side). Mostly, I hear “Houston”, but occasionally “Bayou City” (I even use that term, though infrequently). The media will sometimes use the term “Space City”, especially if it happens to be a story about NASA or the space program.
“H-town” IME is only used by the ‘young’ crowd (ie: under 30).
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I have friends in Irving, Texas (in the Metroplex) that occasionally use that term, though it’s usually said, “Dull-ass”. 
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Likewise, I occasionally hear the ‘city’ of Conroe, Texas referred to as “Corn-row”.
Durgin Park?
Yup: You headin’ to the Cape this weekend?
And apparently I also use the term “Space City”, as evidenced by my profile. :smack:
“Emerald City”, “Rain City”, and although fading out “Jet City” are widely used by businesses, but never in conversation.
Thirty miles south Tacoma tries to brand itself “City of Destiny”, but nobody in real life uses it. “Grit City” is being adopted by businesses, but “T-town” is the default nickname locally.
Also “SLObispo.”
Sorta opposite sitch… in Long Beach, there’s an avenue called “Ximeno.” Most people these days would pronounce it correctly as “he-MEN-o” However, when I was a young lad, most LBers would pronounce it “Ex-IM-en-o”. Make of that what you will.
Thanks to that show, most people now abbreviate all of Orange County, CA as “The O.C.” However, this ignores the fact that the county encompasses every socioeconomic stripe from upper-middle-and-beyond class (Irvine, some parts of Fountain Valley) to working-class-and-below (Garden Grove, Santa Ana.) For instance “Garbage Grove.”
Cleveland is sometimes called “The North Coast,” but most Clevelanders would call it “The Mistake on the Lake.”
Denver has long been called the Mile High City. Since legalizing Mary Jane it’s being used a lot more.
As mentioned up-thread, Birmingham is sometimes Brum, but more often Birningam. Portsmouth, and its football team, is Pompey, Bristol is Bristle and Cirencester used to be called Cissister by locals. An area to the North West of Birmingham, around Lye mainly, is known as The Black Country. This is nothing whatsoever to do with race.
And in the adjacent cities of Pebble Beach and Pacific Grove, CA, there is a residential road named Sinex. I have no idea what the correct pronunciation is. But what I have heard is that the locals there can always tell who the visitors are because visitors always get it wrong.
I suspect that the wrong pronunciation used by visitors is “Seenex” (rhymes with Kleenex), while the right pronunciation is probably “SINnex” (first syllable rhymes with tin).
ETA: I mean, Pebble Beach and Pacific Grove are adjacent to each other, not that they are adjacent to Long Beach 
They are in the vicinity of Monterey.
Folks around here sometimes use “Oaktown” for “Oakland.” People sometimes jokingly refer to Berkeley as “Berserkely” or “The People’s Republic of Berkeley.” Placerville is sometimes called “Hangtown.”
Sacramento is sometimes Sack-o-tomatoes, but it’s also referred to as The City of Trees and the River City.
The Los Angeles suburb of San Pedro is pronounced PEE-dro. I always want it to be PAY-dro, but, nope.
When the San Francisco Warriors (now the Golden State Warriors since they moved to Oakland) were actually in San Francisco, they had THE CITY proudly emblazoned on their uniforms.
My best friend lived in Los Gatos for years and informs me has has never in his life heard anyone call it “LG.”
Toronto’s old nickname was “Hogtown,” but this has fallen into disuse inasmuch as it no longer makes any sense. Residents sometimes call it “T-O,” which is boring.
Orlando residents sometimes use “O-Town”. We never say “The City Beautiful” or “The City of Magic” or any of the other stupid nicknames that mayors like.
Yeah, I’ve lived in the Bay Area for 25 years and never heard it called that either. I’ve heard Palo Alto called “PA” and (even more commonly) East Palo Alto called “EPA,” though.
We live in the Chicago 'burbs, and the reason we just say we’re from Chicago is because it saves us from having to give a five-minute explanation of where our obscure suburb is actually located relative to places around Chicago someone might actually have heard of. It has nothing to do with pretending or wishful thinking. Trust me on this.
Otherwise, if we’re going into the city for a party, dinner or whatever, we just use the name of the neighborhood or area - Downtown, Lincoln Park, Greektown, Nort’ Side, Sout’ Side, whatever. Or just “the city”.
Our group (mostly Sout’ Side refugees) used to call it Daley City but that name was eventually retired. 
I’d argue that that’s an accent thing rather than anyone actually trying to say that. And I don’t agree with the “n” either.
Grew up in Warwickshire, just over the border from the West Midlands, and lived for five years in Birmingham. Which reminds me, Coventry is “Cov”. Similarly nearby Leamington is Leam. They think long and hard about their nicknames in that part of the country.
Most Clevelanders? I think not!
Most residents call it “Vegas”.
I have never heard a local (well…the few who there are) call it “Sin City” or “Lost Wages”
And any transplant from the Bay Area to Nevada always calls San Francisco “The City” as if it were the only one.
Most Chicagoans tell you what neighborhood they live in or what streets (especially intersections) that they live near (from my 4 1/2 years near 61st Place and Narragansett)