I do not think you can.
Their history only supports a 200 pound animal at its natural largest.
Breeding for a little bigger is one thing, breeding for an animal more than twice it’s biggest ever it asking a miracle i think.
Think about it, the dogs structure is the result of millions of years work.
It does not just change overnight, and it reached a peak maximum a while ago.
Now, you want to double the weight, double or more the stress on the skeleton and joints?
You can not just make a bone bigger and say there, problem solved.
You have to redesign the entire skeleton to bear out these new stresses.
New hip structure, rework the knees, the neck vertebrae etc, new muscle attachment points, different mass, different cartilage, different bone density and composition and on and on.
We have not even discussed things like heart, lungs, nervous system, etc etc.
The castle you build of popsicle sticks, its a wonder on the scale of the popsiscle stick, but when that castle is scaled up and weighs 3M metric tons suddenly the wood planks and elmers glue dont cut it.
You can not simply make something bigger, it comes at a price.
The animal needs an appropriate amount of time for nature to gradually navigate through the required changes, and the required mental/social changes.
500 pound dogs need different teeth, and possibly modified paws.
Because they are going to become solitary animals.
Their eco system does not support a pack animal of 500+ pound appetite each.
So mister dog needs a new mentality to go with the body
And this is Mother Nature we are talking about doing this, she knows how to design shit and knows what she is doing for the most part.
This is a long term project for her at best.
Human beings? trying to play God in a box, overnight no less?
I think you would wind up with a horribly defective creature, with no place in the natural world (And yes i know that describes a lot of designer dogs to a T)
A dog very prone to self injury, tons of skeletal defects, short life with a painful end part.
And if that is the animal you wind up with in your tinkering, i myself do not call that successful.
And yes i realize that means i would not consider a lot of designer animals successful, because they aren’t, if you allowed nature to, she’d kill them.