I have a problem and a solution ( to a different problem ).
Problem : To my knowledge, no one has yet created a perfect vacuum; I can’t provide a cite, but I heard it claimed years ago that a gram of antimatter in the best vacuum produceable would emit enough radiation to kill everyone within half a mile. There’s still to many particles in even the best modern vacuums, so researching improved versions would be a priority.
Why not use the antimatter as a “booster stage” to a fission bomb, just like with thermonuclear weapons ? I can’t think of a practical faster way to mix matter and antimatter than that.