Not sure if this goes in Cafe Society or IMHO
Watching the movie 2001, a Space Odyssey, I thought why not send a husband wife pair up there instead of Frank Poole and Dave Bowman?
Yes, I know that it is a 1960s movie but women were just as capable and their smaller size might actually be an advantage plus one would get a different perspective from a woman than Dave Bowman and Frank Poole (who could be twins the way they looked and acted)
Kubrick had showed a Russian lady scientist on the Space Station so he was certainly open to the idea.
Also, it appears that Peter Hymans in the 2010 sequel showed a lady, Helen Mirren in charge of the probe Leonov plus a second lady navigator.
There has been in real life, a number of astronaut couples
Sally Ride and Steven Hawley
Anna Tingle and William Fisher
Shannon Walker and Andy Thomas
Tammy Jernigan and Pete Wisoff
Bonnie Dunbar and Ron Sega
Rhea Seddon and Hoot Gibson
Karen Nyberg and Doug Hurley
Valentina Tereshkova and Andrian Nikolayev
Yelena Kondakova and Valery Ryumin
Although the only couple to fly together was
Mark Lee and Jan Davis
On a secondary point, running a massive ship like the Discovery with only 2 Astronauts seems like a very slim operating margin. (Yes, I know that Kubrick was trying to show that the HAL 9000 was capable of replacing Humans which is why the crew complement was 2 + 3 more in suspended animation.)
It also allows for a dramatic confrontation between Bowman and Hal once Frank Poole is sabotaged by Hal.
That being said, a close real life parallels to the Discovery would be the Space Shuttle which aside from the test flights usually had a crew of 7.
The second parallel would be a military ship such as ill fated Fitzgerald which has a listed complement of:
33 commissioned officers
38 chief petty officers
210 enlisted personnel
Obviously supporting such a large crew on a long space mission to Jupiter would be a lot more difficult however plot points aside.
Splitting the difference, I would think a crew complement of 10 - 15 (including some ladies) would be more realistic.