Two things come into play when dealing with pesticides: Toxicity and hazard.
Toxicity is what it is. It can’t be changed. It’s like the calories in food. A pesticide has a certain level of toxicity, period.
Hazard is entirely in the hands of the applicator. Reckless application of even a low-toxicity pesticide can have horrible results. Safe application of a high-toxicity pesticide can solve a certain pest problem and not disrupt the surrounding environment/ecosystem.
To illustrate, let’s take it out of the realm of toxic chemicals and controlled substances.
Take gasoline. Any adult can get some. And it’s useful, even necessary in some cases. And if you store and use it properly, you won’t really be creating a hazard. But if you store it in an open coffee can next to your furnace, you’re an idiot.
It may be the case with DDT that hazardous applications made by untrained laypeople caused problems that led to a knee-jerk reaction, result-oriented testing, and the subsequent banning of the substance from US markets.
Understand I say this without cites, without formal research, with nothing, in fact, besides my own experience and training in the pesticide field. I have heard it said, though, (again, no cites) that nearly all the illnesses, injuries, and deaths occurring from pesticide poisoning are the result of improper application by homeowners, not pest control professionals.
And finally, most people don’t realize it, but the vast majority of pesticides in use by both professionals and in over-the-counter formulations have no higher a level of toxicity than household cleansers. In other words, ounce for ounce, Mr. Clean will kill you just as efficiently as Raid.