nailed it
Don’t joke about religion, it makes some people cross.
Was ‘cross’ also a verb in crucifixion times, for the act?
Which meaning of ‘cross’ are you asking about. ‘Cross’ meaning ill-tempered seems to be an adjective and emerged much later.
From here:
Well, one meaning of “cross, v.t.” is to do a thing that is problematic for the verb’s object, and, um, likely make them all cross.
It was just a lame attempt at a joke, to imply that the known current adjective / verb ‘cross’ meant also the act of going on a crucifix in Roman times.