Pfizer and Moderna under discussion here.
Understood : The vaccine is effective no matter the bodily response. Also understand all the simplified examples like : “The first shot is like this … and second shot is like this …”
Science has been wrong in this Covid journey in initial stages : for example scientists misunderstood the spread through surfaces initially. If studies have not been conducted to look into the variability of human response, that’s okay - but I’d like an answer that’s scientifically validated rather than one from “first principles”