'Tis a good point. I guess my answer would then be “Right-handed, twist on clockwise.”
I’m right-handed, but I tend to use my left hand to twist ties. And I twist in an anti-clockwise direction.
Left-handed. I always put them on in the reverse of how I found them. This annoys my wife, which amuses me.
Left-handed, hold item (bread, etc) with left hand, turn twist tie clockwise with right hand.
I don’t twist the ends together (if that is what you mean), I wind them around the end of the thing I am trying to close. I guess I go clockwise mostly with that (right-hander).
I hold the tie around the sack and twirl the bread counterclockwise. 
Note that “Righty tight, lefty loosey” has it’s detractors, starting with me over in this thread.
Right handed, clockwise. You know-- normal.
I am not unique. 
Clockwise motion is just easier. It feels almost like I’m using my left hand if I go the other way.
Actually, I should amend this, having recently put on a twist-tie and paid attention to what I did: I wind with both hands, in both directions at once.
Ends twisted together are such a pain to get off again.
ambidex, right hand clockwise, left counterclockwise.
No preference just depends which hand I grab the bread with.
I turn them away from me, whichever hand I use. Clockwise for right hand, and anti-clockwise for left hand.
clockwise
Add me to the right handed, use the left to close a twist tie counter clockwise.
A rightie, and clockwise like god intended.
I have to change my vote. After voting I went to open a twist tie for a bulk candy purchase I got at the store Friday. I’m right handed and it was closed with a counter clock wise twist. :eek:
Clockwise.
I tried just for your niece.
Usually I throw the damn things away and twist the bag and pull it over the loaf.
If I don’t get to them first and throw them away *somebody *in this house thinks every damn one has to be saved in case we lose one and we all know the earth will stop rotating on its axis and we will all fly off into space if we don’t have hundreds of spare twist ties to save us from such an emergency.
Awhile back I started a poll to find out if left- and right-handed people wring out towels in opposite directions… essentially the same question, and the same hypothesis (basically, left-handers turn their hands counterclockwise, right-handers clockwise). There weren’t enough left-handed responders to come to a firm conclusion, but the results seemed to support the hypothesis.
I’m beginning to suspect these packages are originally closed with a counter clockwise twist so that they can be opened with the easier clockwise untwist for the right handed majority. But I still reclose them using a clockwise twist.
[pedantic]
It’s a mnemonic; it’s intent is not to be perfectly accurate, but to remind you of something. You also need the association in your mind that “righty” means “clockwise” and “lefty” means “counter-clockwise”.
[/pedantic]
Roddy