I’m from the US and had been driving for about 10 years before I moved to the UK and took the UK drivers license exam. I know you’re not going to do that, but based on my experience, I don’t think you’ll have much problem adapting. I found that driving is driving, no matter what side of the car you are on. Just pay attention and let your co-pilot do the searching for streets, hotels, Loch Ness monsters and so forth. That said, the passenger seat feels like a suicide seat for the non-driver. Hell, you’re supposed to be in control from that side of the car! It’s like being in back on a two-seater bicycle with a maniac at the helm.
The mechanics: The foot pedals are in the same place but the gear shift is reversed. I mean, gear 1-2 is closest to the driver. It feels natural pretty quickly but sometimes seems odd, causing you to ask yourself why the engine suddenly sounds like a Formula one racecar and the rpms needle has blown out of the dash. Wear seatbelts! Accidently going into first gear when you were looking for fifth is fun and exciting, but you should at least be buckled in before it happens. Of course, I have never done that no matter what my girlfriend tries to tell you (she is full of lies, lies, lies! Some of which are unfortunately true).
You are always driving with the driver’s side toward traffic, so while from the other side of the car, you still have the same sense of seeing the ‘right edge’, passing side of your car and if you’re going to sideswipe oncoming traffic (which I would suggest avoiding). Mirrors, sense of car width, length, etc. all come quickly. However, I guarantee you that you will turn the windshield wipers on and off about 100 times a day since the turn signal is on the other side of the steering wheel. Also, they tend to use flashers to indicate a slow-down in traffic, to avoid pile-ups so you may want to remember that if you are on the motorways!
And just so that you don’t feel too comfortable and to remind you to pay attention and you’ll be okay, wasn’t Matthew Broderick involved in a horrible accident in Great Britain because he was driving on the wrong side of the road? How does it go again? Left is right and right is wrong…