Drugs and Sleep

How do drugs make people go to sleep?

The barbiturates bind to receptors when the GABA-BZPT-Cl iantephore receptor comples
increase length of time cl channel is open; hyperpolarize neuronal membrane and decrease exicitability of neuron/ CNS depression;
Decrease firing rate of other NT and system that are innervated by BABAergic neurons

Metabolic degradation is from liver-short acting and intermediate acting barbiburates
Renal excretion of unchanged if long acting barbiturate