Give me a completely implausible casting

Anthony Hopkins = Gilligan
DJ Qualls = The Skipper Too
Johnny Knoxville = The Millionaire
Rosanne Barr= And His Wife
Sandra Bernhard = The Movie Star
Hulk Hogan = The Professor
Rosie ODonnell = And Marry Anne

"A census taker once tried to test me. I ate his liver with some bananas and a nice coconut cream pie. "

That could actually work . . .

I was just coming in here to suggest Steven Wright as The Joker - but the one from Batman.

Wally Cox IS Dirty Harry.

Paul Lynde IS Snake Plissken.

Sir Rhosis

How about wooden, one-note surfer dude Keanu Reeves as one of the most revered religious icons the world has ever known?
Actually that film likely also deserves mention in this thread.

Great Googaly Moogaly, I’d pay to see these two!
Harry: Go ahead punk, make my day.

Or this: (You have to imagine Bill Daily as Hauk:

Bob Hauk: You go in, find the President, bring him out in less than 24 hours, and your’re a free man.
Snake Plissken: Bullshit!
Bob Hauk: I’m making you an offer.
Snake Plissken: Get a new president.
Bob Hauk: Is that your answer?
Snake Plissken: I’m thinking about it.
Bob Hauk: Think hard. We’re still at war. We need him alive.
Snake Plissken: I don’t give a f–k about your war… or your president.
This is comedy GOLD!

Danny DeVito as Neo in The Matrix.