In my humble opinion as a firearms instructor with many of these guns listed above and 30+ years of shooting experience, I would recommend the Ruger Mk III, 22/45 RP.
Just like Ford vs. Chevy guys, we gun guys can be just the same!
The 22/45 points well, shoots well, and will last forever. Yes, the re-assembly takes some practice to learn the proper steps for some people, but Youtube is full of good videosto help you do it quickly and correctly. It is not finger re-attachment surgery-hard like some people say.
Some people don’t like magazine disconnect, but I don’t use mine as a self-defense weapon, although it’s certainly capable. It’s not a deal-breaker for me.
The other reason I like the 22/45 is the RP version. That stands for replaceable panel. You can change the side panels on the grip to whatever you like, and it takes standard .45 grips, so there are hundreds of styles, colors and materials to choose from. If you don’t care, get the standard 22/45.
If you shop around or hit a gun show, you should be able to pick one up for $260 to $300 anytime.
Now, while I love the MkIII, they can be on the heavy side with the bull barrel. They come in 4 to 6 inch models, some fluted for a little weight savings.
The best thing for the Mk II and III series is an aftermarket upper from Tactical Solutions.It is the serial-numbered part of the gun, so it’s like buying another gun; you’ll have to get it from a dealer. That also means it costs another $279 or so. It’s not necessary, but if you ever pick up a MkIII with one on, you’ll fall in love.
They are light-weight aluminum, come in many colors, fluted or plain, and best of all - threaded! You do want a suppressor on it, right?
Here’smine with an in-expensive red-dot sight on it. Note the Pac-Lite upper on it.
Hereyou can see the thread-protector removed and ready for attachment…
And hereis what you need for covert squirrel or pesky neighbor kid control!
The bottom line is you can get the basic gun that will serve you well for years, but with the option to improve and enhance it in the future at your convenience.
The Browning Buckmark is the only other one you can modify in the future. All the others are WYSIWYG.
I second the opions above: the Sig Mosquito is cute and un-reliable.
The Walther P-22 is cool and in-accurate.
The Bersa is cute and adequate, but just doesn’t have the quality I want in a gun, even if it’s only for shooting cans & such.
If you have any questions, PM me, or put 'em here & we’ll all hash it out!
Good on ya for having a gun gal. They’re the best kind.