This is actually a very good post. I find it interesting on many levels.
Since the OP mentioned us possibly evolving into creatures with large brains/small bodies, I assume the crux of the question deals with whether we will actually see physical changes as we become more intelligent.
I would like to offer up something that came to mind while reading the replies.
Firstly, since we now only use a very small portion of our brains anyway, I don’t see a human actually needing to develop a larger brain to become smarter.
Secondly and slightly off course, the smaller body may actually occur. Well, maybe not smaller but almost assuredly different. With the technology available today we artificially sustain children that nature would have removed from the gene pool. My own daughter was born with a congenital heart defect that was remedied with surgery, without which she would have only lived a few years. The question of whether this surgery should be done was a no-brainer, of course, and we didn’t hesitate at all to have it done. But, I remember noticing how this fit into the greater scheme of things. We have essentially taken natural selection out of the mix. (of course all defects cannot be fixed as such, so natural selection still does it’s dirty work, just less of it.) So, it would seem, we can expect to see a noticable difference in the human body as we evolve, or would this be de-evolving?
Thirdly, is a question within this question we can ponder. Can we safely assume that we are actually smarter than our forebearers? If we were to take some of histories greatest thinkers, bring them up to date with all technology has given us to this point, would they be less smart or more smart than our contemporary thinkers?
I would be interested to see what DaVinci, Michelangelo or Socrates could make of today’s unanswered questions. But, I would be most interested in seeing what the great Egyptian designers of the pyramids could accomplish if they had the benefit of what we know now. With their ability to grasp abstract ideas of mathematics (remember that Pi had yet to be identified) and their apparent knowledge of astronomy (the portholes through the pyramids were most probably used as some sort of astronomer’s tool and used the concepts of precession in their placement).
One would think that, if we were indeed smarter than these individuals, after several thousands of years, we would already see the large brain/small body in all of us.