Help me remember this movie about a couple and how they grow more distant over many years

It occurs to me you might be thinking of Raging Bull (1980).

DeNiro really does appear to age, but not entirely through makeup. He gained something like 60 pounds to play the role of Jake LaMotta.

As for his marriage … IIRC, he knocks his pregnant wife down and kicks her until she aborts, all because he doesn’t like the way she cooked his steak.

Aside from the boxing scenes, which are brutal, the movie is memorable for being shot in B&W.

But Henry & Karen didn’t really grow apart during the movie. She threatened to kill him when she found out he was cheating (again), but she was with him to the very end - she was with him when he was talking to the federal prosecutor about witness protection, claiming Henry couldn’t go anywhere too cold because he’s bronchial.