It starts out on a plane - Leona and Crandall sitting side by side. She has a hallucination of water coming through the plane and heart issues. Opening credits. House at home, pacing. His leg obviously hurts much more than usual. He’s fumbling with a lock box with morphine in it when the phone rings. Cuddy comes on the machine telling him about a 16-year old girl with such and such symptoms. He comes to the hospital and sees Crandall, who was a friend from his youth (good line - Cuddy saying “I thought I knew all your friend.”). Cuddy also gives him some medical profiles of potential sperm donors. Crandall tells House the girl’s grandfather was a famous musician. D.B. Sweeney (the white guy) had done a book on him years before. She’d lost everything in Katrina, then contacted Crandall (Sweeney) telling him he was her father. House thinks she’s scamming Crandall. He agrees to treat the girl and does a test that checks the electrifcal pathways of her heart and finds the bad one. They fix it with some sort of freezing technique and he says she’s cured. She’ll be fine by breakfast. Of course it can’t be that simple.
House goes to see Cuddy and tells her all the potential daddies are losers, and that she needs to know the person before deciding on whether he should be a dad, because there’s more to it than can be read in a medical and genetic history. (House - “You’re designing a kid, a loser kid. He’s already getting pummeled on the playground.”) Cut to the kid, who has another hallucination, of her dead mother in Katrina. THe team is brainstorming, meanwhile House is pacing like a madman. THey decide maybe the hallucinations are a weird pain reaction from an auto-immune reaction. They put her in a PET scan and House tortures the girl (which was very hard to watch). He provokes a hallucination by hurting her. They put her on the bone marrow registry. Throughout, Crandall refuses to have a paternity test done.
Clinic patient - little boy with a red rash on his face in chest. Mother concerned - House diagnoses a new couch, with the dye rubbing off on hte kid. Bingo! Cuddy asks House to give her twice-daily injections for the fertility treatments. House again tells her that she should be more care picking her potential baby daddy. Later he’s talking to Wilson while the girl is under-going radiation (probably to kill her bone marrow pt\rior to the transplant) and explains that he was friends with Crandall because when they were 20 Crandall had a car. If he’d been a woman, House would’ve married him. They look at the girl and this nasty jelly-ish substance is oozing from her mouth. It’s (eww) a mixture of blood and fecal matter. Her digestive system has reversed itself. Reverse peristalsis. A liver biopsy is needed to determine what the real problem is. House is talking to Wilson, who is eating lunch. He tries to gross Wilson out but Wilson’s an oncologist - a little poop from someone’s mouth won’t keep him from eating his chicken mole’. He tells Wilson that he broke up a relationship Crandall had with a prior girlfriend, because she was nuts. Cameron is just about to poke her with a huge needle while House is listening to a recording of her Grandfather’s music. He pages the OR and tells them to stop the presses, he knows what it is. She has a hereditary disease which her alcoholic musician gransfather had, too much iron - hemochromatosis. They’ll treat it and she’ll be fine by lunch.
House introduces Cuddy to a new candidate for a rotating intern. He’s a real geek, and it turns out to be Cuddy’s top sperm donor candidate. She’s not impressed. They treat the iron, but something goes horribly wrong - the iron her blood goes to the lungs, where it bonds with the oxygen and starts coming out the walls. Whoops! There must be a fungal infection! What’s the fungus? He picks a common one, and the start treatment. Cuddy gets her second shot, House telling her, “Genes matter. Who you are matters. You should chose someone you trust.” Cuddy - “Someone like you?” House - “Someone you like.”
House gets Inga to massage his leg. Wilson walks in. Cameron walks in. The fungal treatment isn’t working. They need to find out where she’s been saying so they can treat the right fungus. House privately gets her to admit that she’s been lying to Crandall about being his daughter, being in a Children’s Shelter. He finds out she’d been staying in her grandfather’s recording studio. They decide the sound-proofing material would hold moisture, giving them a new kind of fungus to try. She’ll be fine by dinner.
Cuddy comes down and stares for a while at house, then thanks him for giving her the injections. She walks away. House tells Leona that she only thought she’d lied when she said Crandall was her father. He ran a paternity test and Crandall is her dad.
End scene - house lying on his couch lookking at hte paternity test results, which say Crandall wasn’t leona’s father. He puts the sheet down on the table next to an empty morphine needle. Fade to black.
