Urk? That must save on ammo cost.
Strictly speaking, there is no “locked and cocked” on a Glock, lacking, as they do, a manual safety. (Yes, a few prototypes did have an external sear lock but that was never offered on a production arm.) A Glock is essentially in Condition 0 when a round is chambered. Not a problem as long as you follow Rule 2 (“Never let the muzzle cover anything you are unwilling to destroy,”) and Rule 3 (“Finger off the trigger until the sights are on the target,”) but the untrained or inattentive will commit grevious errors.
Again, the Sig P220 has no external safety (not counting the new P220R SAO), so can’t be carried in Condition 1. Being a double action pistol, it is normally carried in Condition 2, and after firing the decocker should be used to lower the hammer (while the muzzle is pointed in a safe direction). The USP can be locked and cocked in Variants 1, 2, 9, and 10, but not the other configurations. Both are top notch firearms in any chambering (9mmP, .40 S&W, .45 ACP, as well as aftermarket barrels for .357 Sig, .400 CorBon).