Does anyone know how or if coffee grinds can be dissolved?I have tried lime away,muratic acid and didn’t even soften them. 
What are you trying to accomplish?
Making your own instant coffee, or cleaning up a mess?
If you’re trying to clean, get some commercial coffee pot cleaner such as “Clean That Pot!” or “Squeak’n Clean” - you probably won’t find them at the grocery store, but restaurant supply shops or places like Smart and Final should have it. It’s dirt cheap as well - about two or three bucks a bottle.
FWIW, the stuff is alkaline - Clean That Pot is listed as pH 11.6, so acid is probably the wrong thing to use in the first place.
As gotpasswords mentioned, it really depends on what you are trying to accomplish. Your biggest problen, I think, will be dissolving the polysacharides that make up the structure of the bean. Any process that accomplishes dissolving those, is likely to destroy any chemicals of interest.
Also, dissolving these polysacharides is going to require some pretty harsh conditions. It is not something you will be able to do in a saucepan on the stove. You will need a hood, proper flasks, a reflux condensor, a stir plate, a heating mantle, gloves, goggles … you get the idea.
Thanks guys,I should have noted what I am trying to accomplish is to unclog an espresso filter with microscopic holes.Thanks all
I looked around and found a few suggestions. One was to run the espresso machine without coffee several times, but I’m sure you’ve tried that. The other one I would be a bit cautious about. It suggested burning the coffee grounds by holding it over a burner for a bit. I would be a little concerned about how this would effect the metal though so I wouldn’t go crazy with it. On the other hand, if the espresso maker is useless as is, you can’t lose by trying. Wash it thoroughly after you do this, because you don’t want oxidized metal in your espresso.
I’ve had a problem with my espresso maker that seemed like the filter was clogged. Actually, it turned out that I was over filling the filter. You might want to make sure that you are following all the directions for your particular model. There might not be anything wrong at all.
How about leaving it in a bowl of water overnight?
In that case, Clean That Pot is exactly what you need. Soak the business end of your portafilter in a 50-50 mix of cleaner and **hot ** water for an hour or two in a coffee mug (or whatever the thing will fit into) and it should come clean as the day it was new. Then, pull a couple of “blanks” to flush it.
Of course, you probably also need to clean the group head and everything else… Have a look here for more detailed info.