I apologize in advance for the highjack, but you brought up a question I’ve been wondering about for several years. What actually happens when a medicine expires? Is it degradation of the active ingredients or some other process? And what does the degradation (if it happens) produce?
I had a similar experience a couple months ago. I had a mild headache and was out of headache stuff, I usually use ketoprofen or tylenol because Advil eats my stomach lining. They had no ketoprofen and there were so many different options of tylenol and combinations I couldn’t decide. I almost bought Excedrin Migraine but said to myself “this isn’t a migraine and I haven’t had one of those in a while” so I ended up buying nothing and got a migraine a few days later.
Just to further add to confusion:
Excedrin Migraine is EXACTLY the same as regular Excedrin (which is a combination of aspirin, acetaminophen (Tylenol) and caffeine). It’s just marketing. I had the most difficult time convincing my girlfriend that this was true, but, I assure you, it is.
My neurologist recommended the Advil gel-tabs for my migraines because they dissolve and get into your system faster.
And yes, the so-called ‘migraine’ version of Excedrin is the same as the regular version, but is usually a dollar or two more. It’s all marketing. You’re paying more for the words on the box. Regular Excedrin has always had caffeine.
IANAPharmacist, but my brother is, and I asked him this once. My understanding is that with most medicines, especially over the counter, when they expire, the most likely result is that they will just not work as well. It’s not a good idea to keep expired medicines around anyway, though.
And the Excedrin Migraine thing has had me :rolleyes: for years. Don’t people read labels?
well, are your red eyes from skunk, white rhino, red hair, purple haze, or northern lights? …
as to the op, as long as the dosage is the same amount of active ingredient, it shouldn’t matter much if at all, though a liquid suspension in a gelatin capsule will probably reach your bloodstream slightly, though i doubt significantly, faster than a solid tablet. you might have fewer side effects (i.e upset stomach, heartburn) with one version over another, or you may just find one easier to swallow than the others (due to shape, and/or coating.)
though do note that asa & ibuprofen are safer than acetaminophen when your headache may coincide with the metabolization of alcohol, or especially if alcohol may be consumed after taking such a pain reliever.
They offer different versions so that* their* brand takes up more space that other brands could be in, thus increasing sales for *their *brand. :rolleyes:
What you want is to get the cheapest generic Ibrupropen they have.
And as for Tylenol, two caveats: you can buy generic Acetaminophen at less than 1/4 the cost of Tylenol, and you can buy extra strength formulae too. Next: an overdose of as little as twice the recommended daily dose can lead to liver failure (most dangerous when combined with booze), which is very very bad. The problem is that Acetaminophen hides in many OTC remedies, like cold medicines. So you take two extra strength Tylenol + chug back a dose of Nyquil and do that a few times and you wake up in the ER.
Actually, I do read labels*. That was what was driving me nuts was trying to compare all the generics with the name brands because I wanted the cheaper generics but I also wanted a smallish coated tablet and not one of those footlong caplets that always get stuck in my throat. I noticed that there were a few different Excedrin’s and at least one had different ingredients so I apparently misremembered it as the original not having caffeine, when it was probably another formula. like the Tension Headache. I ended up not buying anything that day and a few days later when I got a migraine I had nothing to take for it. It wasn’t until later the next day that I managed to drag myself out and buy something. Unfortunately, I went to a different place with less choices and no generic option of the tylenol/aspirin/caffeine combo and had to buy the Excedrin Migraine anyway. But at least it helped, then again the headache intensity was a lot less by then.
*I don’t just read the ingredients I read the strength. I learned this lesson a long time ago when I took an OTC antihistamine with pseudoephedrine in it, I figured it was the same as the Sudafed I usually took. Then I had a couple cups of coffee. I was bouncing off the walls and thought I was going to have a heart attack. The medicine I took had a lot more pseudoephedrine in it than the Sudafed I was used to taking with coffee.
I’m thinking, because some folks like one form better than others. Probably the most common reason for a preference is, ease of swallowing. If you’re like me, and you can toss three or four horse pills in your mouth at the same time and gulp 'em right down, you may not care which kind you use. However, if you’re like my wife, and you have a major psychological block when it comes to pills and you have to put even the tiniest pill way on the back of your tongue and gulp and still gag, you may want something small and gel-coated, and the extra buck or two will be worth it to you.
That thread covers a lot of the basics (of course, I’m the one who answered it, so I am biased!)
As for the many different formulations of the same drug: marketing. If you can come up with a “new” version of your drug product, you can keep it’s name in the public mind and sell more and therefore make more money.
There are also (as I understand it) certain patent rights which could be extended if a drug can be shown to treat more than one condition, so you might have the same medicine advertised as a different product.
There are certain advantages (and disadvantages) to gel/liquid capsules vs tablets or regular powder capsules but I’m afraid I’m not completely familiar with them. Ease of swallowing and rapid dose delivery do play a role, though.