My condolences
(I lived there for 15 years).
Ditto on the NW freeway commute. I used to go out to 34th Street (from the Heights) at 6am, then come back in at 8am. The commute out? 10 minutes. The commute back? At least 30 minutes (without an accident - just people slowing down).
Most of the places I know are down in Montrose/Heights/River Oaks.
Mexican food:
Spanish Flower (Heights, relatively cheap, open 24 hours)
Cafe Adobe (Montrose/River Oaks, on Westheimer, OK food, great “funky” atmosphere). Warning, it can get busy, so plan ahead.
Tila’s (on Shepherd, GREAT food, GREAT margaritas - especially the El Tesoro Anejo ones, moderately priced)
Hugo’s (on Westheimer just east of Dunlavy, *real * cabrito, margaritas made with mescal that are so good you’ll go blind - no, really, bring a designated driver).
La Jaliscience (on Montrose, inbetween Fairview and West Gray, cheap, OK food).
The best damn chicken-fried steak is in River Oaks at a place called Ouisie’s Table. Call and ask for chicken-fried steak night (I think it’s Tuesday) and bring a BIG appetite. It is a pretty pricey place - where River Oaks goes for comfort food.
Mo Mong (on Westheimer, west of Montrose) is Vietnamese fusion and is very very tasty. There’s also Van Loc (closer to downtown) which has more authentic Vietnamese food.
You’re making me very hungry. 
Half Price Bookstores has several locations throughout the city. The biggest store is down in Rice Village. It’s a great place to waste a LOT of time and spend some cash.
There is the River Oaks Theatre (on West Gray near Shepherd); it’s the art-housy independent theatre in the Montrose/River Oaks area. They also do midnight movies (at least they used to).
If you rollerblade (and are good at it), see if you can find a listing for Urban Animals. They go terrorize downtown on blades. Warning - if they invite you to skate the “Jesus Saves” parking garage, do NOT do it unless you’re REALLY good.
Traffic is a right bitch, if you’re a freeway user. Best idea is to stay away from freeways entirely during rush hour. If you’re living closer to or inside “the loop” (610), you can get around pretty easily on surface streets. If you’re out 290, well, not as easy.
There’s plenty more stuff … lots of theatre around, concerts (out at Cynthia Woods Pavilion, which is about an hour north of town), live music. Ask if ya wanna know.
Where are you going to live?