There are several variables. Time, cost and stress.
For time, you can probably drive a 60 mph, but you also have to stop to sleep, eat, and pee.
But in an airplane, you’ve got two hours on either end of your flight that are just dead, eaten up by getting on the plane, getting through security, getting your bags, and so on. Then add the flight time. If the flight time plus 4 hours is less than the drive time, then it’s faster to fly.
Then cost, you’ve got gas, food, lodging, depreciation on your car, chance of wrecking your car, chance of falling asleep at the wheel and crossing the median and waking up dead, vs the cost of the ticket and possibly a rental car and transport to and from the airport on both ends.
Then the stress. If you’re driving in a rainstorm, through heavy traffic, through an industrial wasteland, or what have you, that’s a factor. If you’re claustrophobic, have a fear of heights, or have control issues, that’s another. Some people find driving relaxing and fun. Others find it tiring and stressful.
So figure out how each variable looks, and weigh the costs, two people with the exact same options can rationally make differnet choices.