It’s not a question of how “tough” ice plant is. If you use a selective herbicide, it will kill things that it is supposed to kill and will not harm things that it is not supposed to harm. I have used broad-leafed weed killer around liriope and it doesn’t seem to harm the liriope at all. That doesn’t mean that liriope is the world’s toughest plant.
“Weed killer for iceplant” says right on it that it only works in iceplant.
Iceplant is popular for 2 reasons, well 3, well…
1-It has flowers that look lovely at the right time of year, adding a blanket of color to scenic highway overpasses.
2-It forms a tight net over steep slopes, making it good for keeping overpass butress dirt from sliding onto the roadway.
3-It can tolerate salt air.
4-It can outlast a drought. Even if dead, the roots all interconnect to retain the soil, and it will grow back the next rainy season.
5-It’s hard to walk on, so it keeps people to the pathways and off the parking berms.