Ohio was more Republican than the country in the last five elections except for 2004, when it was even.
So if Ohio is bluer than the rest of the country, that is in fact significant. Not to mention, Ohio was even more Republican than average in 2010. So yes, going bluer than the country in 2012 would be a significant shift.
I’m going to go out on a limb and make a prediction: Romney wins Ohio 51-48. Reason: The polls in Ohio are skewed by Obama voters falsely claiming to have voted when they haven’t.