[QUOTE=KlondikeGeoff]
For crying out loud, what is the *harm *is getting the DRE and PSA even if they are not 100 percent? Even if a false positive occurs now and then, is it not still better to get checked regularly with the best of the tests we have now? The worst that could happen would be you would get a biopsy that proved negative. Painful, perhaps but not life-threatening.
[/QUOTE]
Because the treatment may be worse than the disease.
Given the high rate of false positives, and also given the high rate at which many cases of prostate cancer never go on to cause morbidity or mortality, more people may be sickened, and more people may die from, the biopsies and subsequent treatments than are saved by treatments for the cancer.
And that’s it, plain and simple.
The first thing I learned in medicine was Primum non nocere. “First, do no harm”.
If, in my career, I screen 10,000 people for prostate cancer, and catch it early enough to save 20 of them, That’d be good, right?
Not if to save those 20 of them, 23 of them also die of complications of biopsy or complications of the treatment.
That’s what the experts are arguing about. We may be harming more people than we help if we screen every male 50 and over with PSA and DRE.
Until it can be conclusively shown that mass screening helps more than it harms, I can’t recommend it.
I do screen high risk populations, like older african-americans, and those with a strong family history.
I also screen patients who have symptoms or signs suggestive prostate trouble.
But age and male gender alone thus far don’t automatically mean one must be screened.