Kleenex probably kills more insects than all the leading chemical products combined.
One on my desk next to me. One in the kitchen. One in the living room. One in the bedroom. One in the car. One on my husband’s desk. One in husband’s car. Five unopened boxes in the bottom of the linen closet.
They’re especially important during sleeveless shirt season! 
I just counted. 2,000 sq ft house, 5 bedrooms 2 1/2 baths - 11 also. 2 of the bedrooms are offices, one each in there. one each in our kids rooms even though they are long gone - just in case. 2 in our bedroom. 1 in each bathroom, and 1 in the kitchen and 1 in the living room we use.
I got it honestly. 30 years ago my brother’s girlfriend, visiting my parents’ apartment and seeing multiple tissue boxes, said “you are very nosy people.”
And hooray for Costco, the best place to get the tissues.
I didn’t realize people had so many in their homes. Are any of these housed in cutesy tissue box holders? This could explain why my sister-in-law does such a good business at craft fairs with her holders. They are couch-shaped fabric holders and you pull the tissues out of the seat. She has them in all sorts of prints and her biggest sellers are sports teams. She’s been selling them for years and I always thought there had to be a ceiling at some point because surely by now everyone in the tri-state area has one. I guess she does have a good business model with homes having multiple boxes.
I only have one box of tissues - on the end table in my living room. I own two of her couches (cats design) that she gave me as gifts but they are in a closet.
Two kids, wife, me. I think we have one box of Kleenex currently somewhere. Don’t know which room though, probably bedroom. (Oh, wait, there may be one in my wife’s office, too.) Back when I lived alone or with my brother, we kept zero boxes of Kleenex around. I just use a paper towel when I get sniffly.
One by my bed. One on my desk at work. Plus there’s a roll of toilet paper in each of the bathrooms, and paper towels in the kitchen. Paper towels aren’t good for noses, but they are fine for my (glass) glasses. and some other stuff I might use tissues for in other rooms.
Just figured. I have one box in every single room of my house, and 2 in some rooms. Because I want one handy when I need one, without having to run to somewhere else in the house.
There is one box here in our 2 person, 1700 sq ft house. It was here when we moved in. I can’t remember when I last bought a box of tissues.
We have two boxes of kleenex, but they’re for guests. One stays in the guest bedroom and there is one for the living room that stays in a cabinet most of the time. Both are about five years old.
I guess we just need something more substantial than a kleenex to blow our noses into and both toilet paper and paper towels work better. There are three bathrooms for the TP, paper towels are in the kitchen, laundry room, and at my workbench in the garage so they’re never far away should the need arise.
I just head to the bathroom and use the toilet paper.
I have a couple of boxes of kleenex in the cabinet (unopened) that I purchases a few years ago.
To clean my glasses, I buy the eye glass cleaner and wipes (Each sheet can be used for a week). So every year or so I have to buy that stuff.
Currently 0 boxes, my seasonal spring sniffles are over. Never have more than 2 going at the same time. 1 upstairs , 1 down. I have a smallish place, I don’t like the clutter of a box in every room. Besides there’s usually a perfectly good wad in my pocket. Speaking of tissue wads, I hate when one goes through the wash and dryer. Lint everywhere!
I don’t know how you manage without tissues! I have no conventional allergies, and no discomfort/congestion most of the time, but something causes my nose to run all the time - I’d say the big three causes are temperature-hot food, spicy-hot food, and exercise. (Not uncommon - I guess it is called “exercise-induced rhinitis”). Even slightly cold weather also make my nose drip, but fortunately I don’t encounter too much of that in Hawai’i.
So I have 4 boxes of tissue in my 5-room apartment: one on my office desk, one by my bed, one in the bathroom, and one in the living room/dining room area.
I don’t use boxes tissues, generally, for anything at all. I use flannel rags (torn up worn-out flannel bedsheets) for all those things, except when I have a cold, which is very rare these days. Then I use a roll of toilet tissue.
If I am having overnight guests (not happening now, obviously) I will do up their bedrooms with a box of tissue, a set of clean towels, a night light. That’s the only time I buy it.
I do have a roll of paper towels in the kitchen, it takes about a year to go through one. I’m morally opposed to our let’s-turn-the-whole-world-to-trash culture, and this is one of my tiny stabs at non-participation in it.
OP here. I feel a little better; it seems I’m far from alone.
Things we’ve learned:
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Many people use TP for nose-blowing. I’ve never done that except in an kleenex-less emergency and think TP is vastly inferior to kleenex for nose-blowing. Obviously YMMV.
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Of folks who use kleenex at all, they either have many boxes to hand, or maybe just one hiding in each bathroom. Which sorta makes sense. You either are, or are not, willing to go traipsing across the house whenever you need one.
Answering @aurora_maire's question ... No, none of my open boxes are in any kind of holder or disguise. I despise those things; they're tchotchkes of the worst order & anti-functional to boot. I'm glad your SIL is making a nice living from them, but it's not from me.
Parents
2 in their bedroom
1 in each bathroom = 3
1 in each office = 2
1 in the kitchen, living room, downstairs = 3
1 in each car = 2
So, 12, not including the spares in the garage.
Us:
1 in master bath, master bedroom, my office, living room = 4
And a few spares in the closet
My husband never uses tissues for blowing his nose.
Not nuts. Not normal. Because there ain’t no such thing.
Every time I go to my sister-in-law’s house I buy a box of kleenex, because she only uses toilet paper. And every time I visit, I get a cold (allergic to dogs (has one), cats (has two), grass (15 acres) and mold (everybody has some)), so I just got used to buying a box of kleenex. I’ve never finished it, but I definitely make a dent in it. Doesn’t matter if I’m there for 2 days or 2 weeks, I’m buying a box of kleenex. I will use toilet paper, but she has a septic tank, so the paper is a bit thin.
My wife and I are in 1000 sq ft, and we have one in each room except the dining room, so 7. I could live without many of them, but my wife likes to have a box handy most of the time.
When I lived alone, 0. In my practice office, where people cry, 1-2. With a lovely wife, 4-6 around the house. This metric also works for waste baskets.
Actual Kleenex brand tissues will survive the laundry - my mother used to retrieve them and use them herself.
I was going to vote “nuts” but the majority seems to think “normal” to have Kleenex everywhere. 
I’m in a medium-sized three-bedroom three-bathroom house, two stories with a finished rec room in the basement, and my standard Kleenex outlay is just three boxes going at one time, with currently 8 spares in the linen closet. One in the main upstairs bathroom, one in the bedroom ensuite bathroom, and another, rather oddly, in the breakfast nook just off the kitchen. That last one is because I sometimes randomly get the sniffles, often while cooking, so it’s handy there. (Not COVID related – this sniffle thing has been on and off for about two years!).
Viva paper towels are also nearly indestructible.